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Flashcards in Ethanol and the CNS Deck (4)
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1

What is the strongest bond ethanol is capable of making? What are the implications?

Hydrogen bond

Low affinity binding - high (mM) concentrations required for biological action

2

What is a likely target of acohol-based general anaesthesia?

Excitory (Glutamate) and Inhibitory (GABA and Glycine) neurotransmitters

3

Neurotransmitters bind to the extracellular domain of the Cys-loop Receptors (T/F)

True

4

Ethanol and other and other allosteric regulators bind to the transmembrane domain of the Cys-loop receptors (T/F)

True