Lab values in anemia, Leukopenias, left shift Flashcards Preview

Hematology And Oncology > Lab values in anemia, Leukopenias, left shift > Flashcards

Flashcards in Lab values in anemia, Leukopenias, left shift Deck (16):
1

iron deficiency anemia - iron status

1. low serum iron (1ry)
2. high transferrin or TIBC
3. low ferritin
4. very low trasnferrin saturation (serum iron/TIBC)

2

chronic disease anemia - iron statis

1. low serum iron
2. low trasnferrin or TIBC
3. high ferritin (primary)
4. normal saturation

3

hemochromatosis - iron status

1. high serum iron (primary)
2. low trasnferrin or TIBC
3. high ferritin
4. very high trasnferrin saturation

4

pregnancy/OCP use - iron status

1. serum iron normal
2. trasnferin or TIBC increased (primary)
3. ferritin normal
4. trasnferrin saturation low

5

neutropenia - cell count

less than 1500 cells/mm3

6

neutropenia - severe infections when

less than 500

7

causes of neutropenia

1. Sepsis/postinfection
2. drugs (including chemotherapy)
3. aplastic anemia
4. SLE
5. radiation

8

lymphopenia - cell count

lymphocytes less than 1500 (3000 in children)

9

causes of lymphopenia

1. HIV
2. DiGeiorge
3. SCID
4. SLE
5. corticosteroids
6. radiation
7. sepsis
8. postoperative

10

eosinopenia - cell count

les than 30 cells/mm3

11

causes of eosinopenia

Cushing syndrome
corticosteroinds

12

corticosteroids effects on neutrophils, eosinophils and lymphocytes (and mechanism)

1. neutrophilia --> decrease activation of neutrophil adhesion molecules, imparing migration out of the vasculature at the site of inflammation
2. lymphopenia --> apoptosis
3. eosinopenia --> sequester in lymph nodes

13

Left shift?

increased neutrophil precursor, such as band cells and metamyelocytes

14

left shift usually seen with

neutrophilia in the acute response to infection or inflammation

15

Leukoerythroblastic reaction?

left shift with immature RBCs

16

Leukoerythroblastic reaction - occurs in

1. severe anemia (physiologic response)
2. marrow response (eg. fibrosis, tumor taking up space in marrow)