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Flashcards in other 2 Deck (14):
1

Diamond-Blackfan presentation

1. short stature
2. craniofacial abnormalities
3. upper extremity malformations (triphalangeal thumbs) in 50%

2

fancon anemia - presentation

aplastic anemia, increased risk for tumor/leukemia
- CAFE AU LAIT
- THUMB/RADIAL DEFECTS

3

pleomorpic xanthoastrocytoma

astrocytoma of children + young adults --> rarely progress to GBM
histology: reticulin depositis + chronic inflammatory infiltrates

4

podophylin

inhibits topoisomerase 2 --> treat genital warts

5

causes and diagnosis of hemophagocytic lymphohistiocytosis

familiar (AR), 2ry to EBV
diagnosis: bone marrow --> macrophages engulfing RBCs

6

1. SIS gene - ca
2. TGFA gene - ca
3. HER1 gene - ca

1. proto --> astrocytoma, osteosarcoma
2. proto --> astrocytoma, HCC
3. proto --> scc of lung

7

mutated gene in paroxysmal nocturnal hemoglobinuria

phosphatidyloinositol glycan class A (PIGA gene) --> help on GPI

8

chromosomal rearrangement of non-small cell lung ca

EML4-ALK --> constitutive active tyrosine kinase
Echinoderm mictorubule-associated protein like 4
Anaplastic lymphoma kinase

9

MM cells are susceptible to

protease inhibition due to large proteins that they manufacture (BORTEZOMIB) --> apoptosis

10

OKT3

monoclonal antibody against CD3

11

embryonic hb

gower 1 ζ2ε2
protlant ζ2γ2
gower 2 α2ε2

12

panitumumab?

like cetuximab

13

patrier micro-abscess

by T cells infiltration in the skin (Mycoses fungoides)

14

DLBCL markers

similar with CLL (including CD5+)