Pathologic RBC forms Flashcards Preview

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Flashcards in Pathologic RBC forms Deck (25):
1

Macro-ovalocytes RBCs - seen in

1. megaloblastic anemia (also hypersegmented cells)
2. marrow failure

2

elliptocyte RBCs - seen in

hereditary elliptocytosis

3

bite cells - also called

degmacytes

4

bite cells RBCs - seen in

G6PD deficiency

5

Ringed sideroblasts RBCs - seen in

sideroblastic anemia

6

ringed sedrerblasts RBCs - mechanism

Excess iron in mitochrondria

7

scistocytes RBCs - seen in

1. DIC 2. HELLP syndrome 3. TTP/HUS
4. mechanical hemolysis (heart valve prosthesis)

8

scistocytes RBCs - also called

helmet cells

9

Basophilic stippling RBCs - seen in

1. Lead poisoning
2. sideroblastic anema
3. Myelodisplastic syndromes

10

Acanthocytes RBCs - also called

spur cell

11

Acanthocytes RBCs - seen in

1. liver disease
2. abetalipoproteinemia (states of cholesterol dysregulation)

12

Target RBCs - seen in

1. HbC disease 2. asplenia
3. Liver disease 4. Thalassemia

13

Teardrop RBCs - seen in

bone marrow infiltration (eg. myelofibrosis)

14

Teardrop RBCs - also called

Dacrocytes

15

Spherocytes RBCs - seen in

1. Hereditary spherocytosis
2. drugs and infection induced hemolytic anemia

16

Sickle cells RBCs - seen in

sickle cell anemia

17

sickle cell anemia - sickling occurs with

1. dehydration
2. deoxygenation
3. high altitude

18

Howell-Jolly bodies - seen in

1. asplenia
2. functional hyposplenia

19

Howell-Jolly bodies - mechanism

Basophilic nuclear remnants found in RBCs.
Normally removed from RBCs by splenic macrophages

20

Heinz bodies - seen in

1. G6PD deficiency
2. Heinz body - like inclusions in α-thalassemia

21

Heinz bodies - mechanism

Oxidation of HB-SH groups to S-S --> Hb precipitation (Heinz bodies) --> phagocytic damage to RBC membrane --> bite cells

22

hereditary elliptocytosis - presentation

usually asymptomatic

23

hereditary elliptocytosis - mechanism

mutation in gene encoding RBC membrane proteins (eg. spectrin)

24

Echinocytes vs acanthocytes according to image

Echinocytes projection are more uniform and smaller

25

Echinocytes - seen in

1. end-stage renal disease
2. liver disease
3. pyruvate kinase