Lymphomas Flashcards Preview

Hematology And Oncology > Lymphomas > Flashcards

Flashcards in Lymphomas Deck (63):
1

leukemia vs lymphoma: leukemia

lymphoid or myeloid neoplasm with widespread involvement of bone marrow. Tumor cells are usually found in peripheral blood

2

leukemia vs lymphoma: lymphoma

Discrete tumor mass arising from lymph nodes.

3

Leukemoid reaction

Acute inflammatory response to infection. Increased WBC cound with increased neutrophils and neutrophil precursors such as band cells (left shift)

4

Hodgkin - strongly associated with

EBV

5

non-Hodgkin - may be associated with

1. HIV
2. autoimmune diseases

6

lymphoma - Constitutionals Β signs/symptoms

1. low grade fever
2. night sweats
3. weight loss

7

Hodgkin vs non-Hodgkin lymphoma - Constitutionals Β signs/symptoms

common in Hodgkin
not common in Non-Hodgkin

8

Hodgkin - age

bimodal distribution - young adulthood and >55 years

9

non-Hodgkin lymphoma - age

Peak incidence for certain subtypes at 20-40 years old
(CAN OCCUR IN CHILDREN AND ADULTS)

10

Hodgkin lymphoma - men or women

more common in men except for nodular sclerosing type

11

Hodgkin lymphoma - cells

Reed-Sternberg cells

12

non-Hodgkin lymphoma - cells

B cells
T cells (fewer)

13

non-Hodgkin lymphoma - location

Multiple, peripheral nodes, extranodal involvement common, noncontaguous spread

14

Hodgkin lymphoma - location

Localized, single group of nodes. Extranodal rare. Contiguous spread.

15

Hodgkin vs non-Hodgkin lymphoma - prognosis

prognosis is much better in Hodgkin

16

Hodgkin vs non-Hodgkin lymphoma - stage is stronger predictor of prognosis

Hodgkin lymphoma

17

Reed-Sternberg cells - seen in

Hodgkin lymphoma

18

Reed-Sternberg cells - definition

distinctive tumor giant cell seen in Hodgkin lymphoma

19

Reed-Sternberg cells - histology

binucleate or bilobed with the 2 halves as mirror image (owl eyes)
CD15+ CD30+

20

Reed-Sternberg cells - positive CD

CD15+ CD30+

21

Reed-Sternberg cells - origin

B cells

22

Reed-Sternberg cells for hodgkin diagnosis

necessary but not sufficient

23

Hodgkin lymphoma - mechanims for better prognosis

strong stromal or lympocytic reaction against Reed-Sternberg cells

24

MC Hodgkin lymphoma

Nodular sclerosing

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Hodgkin lymphoma with best prognosis

lymphocyte-rich

26

Hodgkin lymphoma with best prognosis with the worse prognosis

1. lymphocyte mixed
2. depleted forms

27

Non-Hodgkin lymphoma - divided to

1. Lymphomas of mature B cells
2. Lymphomas of mature T cells

28

Non-Hodgkin lymphoma B cells - types

1. Burkitt lymphoma
2. Diffuse large B-cell lymphoma
3. Follicular lymphoma
4. Mantle cell lymphoma
5. Primary central nervous system lymphoma
6. Marginal zone lymphoma

29

Burkitt lymphoma - occurs in (age)

adolescents or young adults

30

Burkitt lymphoma - genetics

t(8;14) - translocation of c-myc (8) and heavy - chain Ig (14)

31

Burkitt lymphoma - histology

starry sky appearance, sheets of lymphocytes with interspersed "tingible body" macrophages

32

Burkitt lymphoma - associated with

EBV

33

Burkitt lymphoma - forms

endemic form (africa)
sporadic form

34

Burkitt lymphoma - endemic form

jaw lesion

35

Burkitt lymphoma - sporadic form

pelvis or abdomen lesion

36

MC type of Non-Hodgkin lymphoma

Diffuse large B-cell lymphoma

37

Diffuse large B-cell lymphoma - occurs in (age)

usually older adults but 20% in chidren

38

Diffuse large B-cell lymphoma - adults or children

usually older adults but 20% in chidren

39

Follicular lymphoma - occurs in (age)

adults

40

Follicular lymphoma - genetics

t(14;18) - translocation of heavy-chain Ig (14) and BCL-2 (18)

41

BCL-2 action

inhibits apoptosis

42

Follicular lymphoma presents with

painless waxing and waning lymphadenopathy (indolent course)

43

Follicular lymphoma - histology

follicular architecture:
small cleaved cells (grade 1)
large cells (grade 3)
mixture (grade 2)

44

Mantle cells lymphoma - occurs in

older males

45

Mantle cells lymphoma - marker/presentation

CD5+
patiens typically present with late stage disease (very aggressive)

46

Mantle cells lymphoma - genetics

t(11:14) - translocation of cycle D1 (11) and heavy-chain Ig (14)

47

Non-Hodgkin lymphoma T cells - types

1. Adults T-cells lymphoma
2. Mycosis fungoides/Sezary syndrome

48

Adults T-cells lymphoma - occurs in

adults

49

Adults T-cells lymphoma is caused by

HTLV (associated with IV drug abuse)

50

HTLV - transmission (associated with)

IV drug abuse

51

Adults T-cells lymphoma - symptoms

1. cutaneous lesions
2, Lytic bone lesions
3. Hypercalcemia

52

Adults T-cells lymphoma - population

1. Japan
2. West Africa
3. Caribbean

53

Mycosis fungoides/Sezary syndrome - occurs in

adults

54

Mycosis fungoides present with

skin patches/plaques (cutaneous T-cell lymphoma)

55

Mycosis fungoides - histology

atypical CD4+ cells with cerebriform nuclei

56

Mycosis fungoides may progress to

Sezary syndrome (T-cell leukemia)

57

Primary central nervous system lymphoma - T or B cells

B

58

Primary central nervous system lymphoma is associated with

HIV/AIDS (nmz me EBV) B

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Primary central nervous system lymphoma is considered as

AIDS-defining illness

60

Primary central nervous system lymphoma - presentation

variable: confusion, memory loss, seizures

61

Primary central nervous system lymphoma - appearance (relevance)

Mass lesion(s) on MRI --> needs to be distinguished from toxoplasmosis via CSF analysis or other lab tsts

62

Marginal zone lymphoma - definition

neoplastic proliferation of small B cells (cd20) that expands the marginal zone

63

Marginal zone lymphoma - associated with

chronic inflammatory states such as Hashimoto, Sjogren, H. Pylori
MALTOMA is marginal zone of mucosal sites