Leukemia

Question 1

Percent of blasts needed to be diagnosed as leukemia

Answer 1

20%

Question 2

Name some genetic abnormalities seen in leukemias

Answer 2

11q23
t(8,21)
t(15,17)
inv(16)

Question 3

This mutation is found in 1/3 of AML cases and involves a mutation of this tyrosine kinase

Answer 3

FLT-3

Question 4

Define DIC

Answer 4

Disseminated Intravascular Coagulation

Question 5

Faggot cells and DIC are indicative of this type of AML

Answer 5

AML-M3

Question 6

When you see Auer rods think this…

Answer 6

AML-M1

Question 7

Which AML types have the worst prognosis?

Answer 7

FLT-3 mutation
Multilineage Dysplasia
Therapy related leukemia

Question 8

Define MDS

Answer 8

myeloplastic dysplagia syndrome

see abnormal stem cells often due to bone marrow failure

Question 9

5 new classifications of AML

Answer 9

1. Genetic abnormalities
2. FLT-3 mutation
3. Multilineage dysplagia
4. Therapy related
5. Not otherwise classified

Question 10

Extramedullary tumors are often seen in these types of AML

Answer 10

AML-4, AML-5

Question 11

Name the AML that is MPO (-)

Answer 11

AML-M0

Question 12

Which type of acute lymphoblastic leukemia is more desirable?

Answer 12

B-lymphoblatic leukemia

Question 13

Which malignant hematopathologies originate in the lymphoid line?

Answer 13

leukemia (acute and chronic)
lymphoma (Hodgkin, non-Hodgkin)
multiple myeloma

Question 14

Things that indicate a good prognosis for ALL

Answer 14

age: 1-10
WBC<10,000
hyperdiploidy
immunotype - B

Question 15

Cells that stain with non-specific esterase

Answer 15

monocytes

Question 16

Neutrophils are stained with this.

Answer 16

Myelo-peroxidase

Question 17

Diagnosis of leukemia is done via these steps

Answer 17

1. Bone marrow biopsy
2. Morphology - stain
3. Flow cytometry
4. cytogenics - karotyping
5. molecular study

Question 18

AML-M6 is dysplagia of this lineage of cells

Answer 18

erythroid