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Flashcards in Treatment Deck (120)
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1

Define Growth Factor

Proportion of cells in a tumor actively involved in cell division

2

Define Generation Time

Length of a cell cycle

3

Define Resting Phase

Cells do not engage in synthetic activity

4

Cell Cycle Specific Chemotherapy Mode of Action

Kills in specific phase of cell cycle
Useful in tumors with high growth index

5

Cell Cycle Non-specific Chemotherapy Mod of Action

Kills in all phases
Useful in tumors with low growth index

6

Which part of the cell cycle does Nitrosoureas act on?

G0 State

7

Which part of the cycle does Asparaginase & Actinomycin D act on?

G1

8

Which medications act on the S phase of the cell cycle?

Antimetabolites
Antifolates
Antipyrimidines
Antipurines

9

Which part of the cell cycle does Bleomycin act on?

G2

10

Which part of the cell cycle does Vinca alkaloids act on?

Mitosis

11

Which medications are phase non-specific?

Alkylating agents
Antitumor antibiotics
Other (cisplatin)

12

What are the 3 modalities for treatment of cancer?

Surgery: definitive, staging, palliative
Chemotherapy: IV vs. oral, neoadjuvent vs. adjuvent
Radiation: definitive, salvage, palliative

13

Define Definitive

Treatment plan that has been chosen as the best one for the patient after all other choices have been considered

14

Define Palliative

Relieving or soothing the symptoms of a disease without producing a cure

15

Means of Administering Systemic Chemotherapy

Intravenously
Injection
Intraperitoneal
Orally
Topically

16

What are the classes of chemotherapy drugs?

Alkylating agents
Antimetabolites
Mitotic inhibitors
Anthracyclines
Topoisomerase inhibitors
Miscellaneous

17

MOA of Alkylating Agents

Directly damage DNA to keep the cell from reproducing
Work in ALL phases of cell cycle

18

What types of cancers are treated with alkylating agents?

Leukemia
Lymphoma
Hodgkin's disease
Multiple myeloma
Sarcoma
Lung
Breast
Ovarian

19

Alkylating Agent Primary Toxicities

N/V
Myelosuppression
Alopecia

20

Classes of Alkylating Agents

Nitrogen mustards
Platinum analogs
Tiazenes
Miscellaneous

21

Nitrogen Mustards Medications (Alkylating Agents)

Mechlorethamine (nitrogen mustard)
Cyclophosphamide (Cytoxan)
Ifosfamide (Ifex)

22

Cyclphosphamide (Cytoxan) SE

Hemorrhagic Cystitis

23

Hemorrhagic Cystitis

May shed large segments of bladder mucosa
May lead to urinary obstruction
Concentrated urine may cause severe bladder damage
Increase fluid intake before & after infusion & empty bladder frequently

24

Platinum Analogues Medications (Alkylating Agents)

Carboplatin (Paraplatin)
Cistplatin (Platinol)
Oxaliplatin (Eloxatin)

25

Cisplatin (Platinol) SE

Nephrotoxicity
Neurotoxicity
Ototoxicity

26

What labs do you need to follow with cisplatin?

CBC
CMP

27

Ways to Prevent Nephrotoxicity with Cisplatin

Vigorously hydrated prior, during, & after administration
Amifostine

28

Ways to Preven Neurotoxicity with Cisplatin

Amifostine

29

What cancer is there a possibility of developing with the use of alkylating agents?

Leukemia: due to damaged DNA, can cause long-term damage to the bone marrow

30

MOA of Antimetabolites

Interfere with DNA & RNA growth by substituting for the normal building blocks of RNA & DNA
Damage during the S phase