Flashcards in Treatment Deck (120)
Define Growth Factor
Proportion of cells in a tumor actively involved in cell division
Define Generation Time
Length of a cell cycle
Define Resting Phase
Cells do not engage in synthetic activity
Cell Cycle Specific Chemotherapy Mode of Action
Kills in specific phase of cell cycle
Useful in tumors with high growth index
Cell Cycle Non-specific Chemotherapy Mod of Action
Kills in all phases
Useful in tumors with low growth index
Which part of the cell cycle does Nitrosoureas act on?
Which part of the cycle does Asparaginase & Actinomycin D act on?
Which medications act on the S phase of the cell cycle?
Which part of the cell cycle does Bleomycin act on?
Which part of the cell cycle does Vinca alkaloids act on?
Which medications are phase non-specific?
What are the 3 modalities for treatment of cancer?
Surgery: definitive, staging, palliative
Chemotherapy: IV vs. oral, neoadjuvent vs. adjuvent
Radiation: definitive, salvage, palliative
Treatment plan that has been chosen as the best one for the patient after all other choices have been considered
Relieving or soothing the symptoms of a disease without producing a cure
Means of Administering Systemic Chemotherapy
What are the classes of chemotherapy drugs?
MOA of Alkylating Agents
Directly damage DNA to keep the cell from reproducing
Work in ALL phases of cell cycle
What types of cancers are treated with alkylating agents?
Alkylating Agent Primary Toxicities
Classes of Alkylating Agents
Nitrogen Mustards Medications (Alkylating Agents)
Mechlorethamine (nitrogen mustard)
Cyclphosphamide (Cytoxan) SE
May shed large segments of bladder mucosa
May lead to urinary obstruction
Concentrated urine may cause severe bladder damage
Increase fluid intake before & after infusion & empty bladder frequently
Platinum Analogues Medications (Alkylating Agents)
Cisplatin (Platinol) SE
What labs do you need to follow with cisplatin?
Ways to Prevent Nephrotoxicity with Cisplatin
Vigorously hydrated prior, during, & after administration
Ways to Preven Neurotoxicity with Cisplatin
What cancer is there a possibility of developing with the use of alkylating agents?
Leukemia: due to damaged DNA, can cause long-term damage to the bone marrow