Flashcards in 11) Genetics of Mood Disorders Deck (11):
How can it be determined if a condition is genetic?
What are the problems in reviewing literature relating to depression?
Lack of biological measure of diagnosis
What do family studies show about depression and bipolar?
Both are inherited
Bipolar leads to increase in BP and depression
Depression leads to increase in depression but not BP
What do twin studies show about depression and bipolar?
Monozygotic twins very likely to both have bipolar, and quite likely to both have depression when compared with dizygotic twins
What do adoption studies show about inheritance of depression?
More likely to be affected if biological parents were affected
What are the two main forms of inheritance in affective disorders?
Hint: SML and QTL
Single major locus
Quantitative trait loci - multiple alleles affecting phenotype
What is linkage?
Co-occurrence of a known disease and know location
What is association?
Co-occurrence of an allele at a particular locus and a disease
What are some genes implicated in depression?
Serotonin transporter gene (chromosome 17)
BDNF gene (chromosome 11)
What are copy number variants?
Sections of genome that are repeated