Flashcards in 11) Genetics of Mood Disorders Deck (11):
1
How can it be determined if a condition is genetic?
Family studies
Twin studies
Adoption studies
Sex differences
Linkage/association
2
What are the problems in reviewing literature relating to depression?
Lack of biological measure of diagnosis
3
What do family studies show about depression and bipolar?
Both are inherited
Bipolar leads to increase in BP and depression
Depression leads to increase in depression but not BP
4
What do twin studies show about depression and bipolar?
Monozygotic twins very likely to both have bipolar, and quite likely to both have depression when compared with dizygotic twins
5
What do adoption studies show about inheritance of depression?
More likely to be affected if biological parents were affected
6
What are the two main forms of inheritance in affective disorders?
Hint: SML and QTL
Single major locus
Quantitative trait loci - multiple alleles affecting phenotype
7
What is linkage?
Co-occurrence of a known disease and know location
8
What is association?
Co-occurrence of an allele at a particular locus and a disease
9
What are some genes implicated in depression?
Serotonin transporter gene (chromosome 17)
BDNF gene (chromosome 11)
10
What are copy number variants?
Sections of genome that are repeated
11