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Flashcards in 8) Pharmacy Deck (23):
1

Why might depression be more common in older people (1 in 5)?

Co-morbid conditions
Not functioning how they used to

2

What is the epidemiology of mental health disorders in prisons?

9 in 10 have a mental health disorder

3

Which gender is more likely to commit suicide?

Male

4

Why does depression need to be treated?

Risk of mortality
High morbidity

5

Describe the stepped care model for treating depression:

Based on severity of depression, there are different steps to treating. From assessment, to medication and therapy to ECT

6

Give some examples of SSRIs:

Citalopram
Fluoxetine
Escitalopram
Sertraline

7

What is the mechanism of SSRIs?

Block reuptake of serotonin into pre-synaptic neurones, increasing serotonin in synaptic cleft

8

What are some side effects of SSRIs?

Nausea
Erectile dysfunction
Weight loss
Agitation
Sleep disturbance

9

What are the main interactions in terms of antidepressants?

SSRI and NSAID - increased risk of bleeding
Citalopram and antipsychotics - increased risk of QT prolongation

10

Give some examples of TCAs:

Amitriptyline
Clomipramine

11

What is the mechanism of TCAs?

Blocking reuptake of NA and serotonin into pre-synaptic neurones

12

What side effect caused TCAs to be phased out?

Cardiotoxic in overdose

13

What are MAOIs and how do they work?

Monoamine oxidase inhibitors
Irreversibly inhibiting action of monoamine oxidase which breaks down NA and serotonin

14

Give some examples of MAOIs:

Phenelzine
Trancypromine

15

What are some side effects of MAOIs?

Nausea
Constipation
Hypertension

16

Give some examples of SNRIs:

Venlafaxine
Duloxetine

17

What is a NaSSA?

Noradrenaline and specific serotonergic agent

18

Give an example of an NaSSA:

Mirtazepine

19

How do NaSSAs work?

Presynaptic alpha 2 receptor antagonist - increase NA and serotonin neurotransmission

20

What is the most cost-effective drug for treating depression?

Mirtazapine

21

How long do anti-depressants take to work?

4-6 weeks

22

How long should the drugs be taken before a dose change?

6 weeks

23

What conditions should be treated with special precautions?

Pregnancy
Breast feeding
Liver failure
Renal failure