Flashcards in 8) Pharmacy Deck (23):
Why might depression be more common in older people (1 in 5)?
Not functioning how they used to
What is the epidemiology of mental health disorders in prisons?
9 in 10 have a mental health disorder
Which gender is more likely to commit suicide?
Why does depression need to be treated?
Risk of mortality
Describe the stepped care model for treating depression:
Based on severity of depression, there are different steps to treating. From assessment, to medication and therapy to ECT
Give some examples of SSRIs:
What is the mechanism of SSRIs?
Block reuptake of serotonin into pre-synaptic neurones, increasing serotonin in synaptic cleft
What are some side effects of SSRIs?
What are the main interactions in terms of antidepressants?
SSRI and NSAID - increased risk of bleeding
Citalopram and antipsychotics - increased risk of QT prolongation
Give some examples of TCAs:
What is the mechanism of TCAs?
Blocking reuptake of NA and serotonin into pre-synaptic neurones
What side effect caused TCAs to be phased out?
Cardiotoxic in overdose
What are MAOIs and how do they work?
Monoamine oxidase inhibitors
Irreversibly inhibiting action of monoamine oxidase which breaks down NA and serotonin
Give some examples of MAOIs:
What are some side effects of MAOIs?
Give some examples of SNRIs:
What is a NaSSA?
Noradrenaline and specific serotonergic agent
Give an example of an NaSSA:
How do NaSSAs work?
Presynaptic alpha 2 receptor antagonist - increase NA and serotonin neurotransmission
What is the most cost-effective drug for treating depression?
How long do anti-depressants take to work?
How long should the drugs be taken before a dose change?