Aetiological Agents Flashcards

1
Q

What cancer does EBV cause + what is the mechanism?

A

Burkitt’s lymphoma Non-Hodgkins lymphoma

Caused by EBNA (Nuclear Antigens) = an 8:14 translocation on chromosome 8 becomes controlled by chromosome 14

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2
Q

What cancer does radiation commonly cause?

A

Leukaemias

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3
Q

Examples of genetic cancers

A

Neurofibromatosis

Adenomatous polyposis coli

Familial breast cancer (BRCA)

Von-Hippel lindau syndrome

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4
Q

Which gene was identified in Li-Fraumeni syndrome?

A

p53

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5
Q

What cancers do the following chemicals cause: aromatic amines, benzenes, wood dust, vinyl chloride?

A

Cigarettes = p53 tumour suppressor gene

Aromatic amines = bladder cancer

Benzene = leukaemia

Wood dust = nasal adenocarcinoma

Vinyl chloride = angiosarcomas

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6
Q

What diets cause cancer?

A

Low fibre = colorectal

Smoked food = gastric cancer

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7
Q

How does Hep B cause cancer?

A

Infection associated with hepatocellular cancer

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8
Q

What cancer is caused by retroviruses?

A

HTLV1 infection = T cell lymphoma

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9
Q

What cancer does H pylori cause?

A

Mucosal associated lymphoid tissue (MALT) tumours

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