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Flashcards in Aetiological Agents Deck (9):
1

What cancer does EBV cause + what is the mechanism?

Burkitt's lymphoma Non-Hodgkins lymphoma

Caused by EBNA (Nuclear Antigens) = an 8:14 translocation on chromosome 8 becomes controlled by chromosome 14

2

What cancer does radiation commonly cause?

Leukaemias

3

Examples of genetic cancers

Neurofibromatosis

Adenomatous polyposis coli

Familial breast cancer (BRCA)

Von-Hippel lindau syndrome

4

Which gene was identified in Li-Fraumeni syndrome?

p53

5

What cancers do the following chemicals cause: aromatic amines, benzenes, wood dust, vinyl chloride? 

Cigarettes = p53 tumour suppressor gene

Aromatic amines = bladder cancer

Benzene = leukaemia

Wood dust = nasal adenocarcinoma

Vinyl chloride = angiosarcomas

6

What diets cause cancer?

Low fibre = colorectal

Smoked food = gastric cancer

7

How does Hep B cause cancer?

Infection associated with hepatocellular cancer

8

What cancer is caused by retroviruses?

HTLV1 infection = T cell lymphoma

9

What cancer does H pylori cause?

Mucosal associated lymphoid tissue (MALT) tumours