What cancer does EBV cause + what is the mechanism?
Burkitt's lymphoma Non-Hodgkins lymphoma
Caused by EBNA (Nuclear Antigens) = an 8:14 translocation on chromosome 8 becomes controlled by chromosome 14
What cancer does radiation commonly cause?
Examples of genetic cancers
Adenomatous polyposis coli
Familial breast cancer (BRCA)
Von-Hippel lindau syndrome
Which gene was identified in Li-Fraumeni syndrome?
What cancers do the following chemicals cause: aromatic amines, benzenes, wood dust, vinyl chloride?
Cigarettes = p53 tumour suppressor gene
Aromatic amines = bladder cancer
Benzene = leukaemia
Wood dust = nasal adenocarcinoma
Vinyl chloride = angiosarcomas
What diets cause cancer?
Low fibre = colorectal
Smoked food = gastric cancer
How does Hep B cause cancer?
Infection associated with hepatocellular cancer
What cancer is caused by retroviruses?
HTLV1 infection = T cell lymphoma
What cancer does H pylori cause?
Mucosal associated lymphoid tissue (MALT) tumours