Flashcards in Myelosuppression Deck (9):
Causes of myelosuppression
Biological therapies eg interferon + interleukin-2
Bone marrow infiltration
How does bone marrow infiltration manifest?
Common in haematological cancers, breast, lung + prostate cancer
What type of anaemia do you get from chemo?
Macrocytic not megaloblastic
How do you investigate myelosuppression?
Blood film, measure haematinics, bone marrow aspirate + trephine
Treatment of thrombocytopenia
Regular platelet infusions - need for single donor or HLA matched platelets
Signs of clinical thrombocytopenia
Petechial haemorrhage, spontaneous nosebleeds, corneal haemorrhage, haematuria
When does neutropenia become a reason for admission?
Total white count <1x10 with fever = immediate inpatient admission + broad spectrum abx
Investigations for neutropenic sepsis
Physical exam (not vaginal or rectal)
Cultures of urine, sputum + throat