Myelosuppression Flashcards Preview

Oncology + Palliative > Myelosuppression > Flashcards

Flashcards in Myelosuppression Deck (9):
1

Causes of myelosuppression

Chemo
Biological therapies eg interferon + interleukin-2
Bone marrow infiltration
Paraneoplastic syndromes

2

How does bone marrow infiltration manifest?

Produces pancytopenia
Common in haematological cancers, breast, lung + prostate cancer

3

What type of anaemia do you get from chemo?

Macrocytic not megaloblastic

4

How do you investigate myelosuppression?

Blood film, measure haematinics, bone marrow aspirate + trephine

5

Treatment of thrombocytopenia

Regular platelet infusions - need for single donor or HLA matched platelets

6

Signs of clinical thrombocytopenia

Petechial haemorrhage, spontaneous nosebleeds, corneal haemorrhage, haematuria

7

When does neutropenia become a reason for admission?

Total white count <1x10 with fever = immediate inpatient admission + broad spectrum abx

8

Investigations for neutropenic sepsis

Physical exam (not vaginal or rectal)
Blood cultures
Cultures of urine, sputum + throat
CXR

9

When are prophylactic abx used?

Use of co-trimoxazole in pts with lymphoma at risk of PCP