Risk + prevention of cancer Flashcards Preview

Oncology + Palliative > Risk + prevention of cancer > Flashcards

Flashcards in Risk + prevention of cancer Deck (8):
1

What cancers are not affected by being overweight? 

Lung, bladder or melanoma

2

Management of women at high risk of breast cancer? 

Offered tamoxifen or raloxifene for 5 years

3

Li Fraumeni syndrome - inheritance, gene affected, common malignancies caused 

Autosomal dominant

Germline mutations to p53 gene

High incidence of malignancies esp. sarcomas + leukaemias

4

What chromosomes are BRCA 1+ 2 carried on?

BRCA 1 = 17 BRCA 2 = 13

5

What cancer is BRCA 2 linked with in men?

Prostate

6

Lynch syndrome - inheritance, common malignancies caused, what criteria used to identify high risk individuals?

Autosomal dominant

Colonic + endometrial cancer at young age

Identify high risk individuals with Amsterdam criteria

7

Gardners - inheritance, gene affected, common malignancies caused 

Autosomal dominant

Colorectal polyposis

Also causes skull osteoma, thyroid cancer + epidermoid cysts Desmoid tumours

Mutation of APC gene on chromosome 5

8

What cancers are not affected by smoking?

Melanoma + brain