What cancers are not affected by being overweight?
Lung, bladder or melanoma
Management of women at high risk of breast cancer?
Offered tamoxifen or raloxifene for 5 years
Li Fraumeni syndrome - inheritance, gene affected, common malignancies caused
Germline mutations to p53 gene
High incidence of malignancies esp. sarcomas + leukaemias
What chromosomes are BRCA 1+ 2 carried on?
BRCA 1 = 17 BRCA 2 = 13
What cancer is BRCA 2 linked with in men?
Lynch syndrome - inheritance, common malignancies caused, what criteria used to identify high risk individuals?
Colonic + endometrial cancer at young age
Identify high risk individuals with Amsterdam criteria
Gardners - inheritance, gene affected, common malignancies caused
Also causes skull osteoma, thyroid cancer + epidermoid cysts Desmoid tumours
Mutation of APC gene on chromosome 5
What cancers are not affected by smoking?
Melanoma + brain