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Clinical Diagnosis > Bone, Joint, Collagen > Flashcards

Flashcards in Bone, Joint, Collagen Deck (37)
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1

what are the clinical features of RA

slow onset
chronic
polyarticular - hands/feet
small joints
low grade fever
myalgia
malaise
fatigue
systemic - heart and lungs

2

what are the lab features of RA

anemia present
WBC normal or increase
RF/RA factor
Anti CCP

3

what percent of people with RA have anemia

40% of men
60% of women

4

in 3% of RA cases, what other problems occur

leukopenia
splenomegaly
RA

= Feltys Syndrome

5

how sensitive is RA/RF factor for rheumatoid arthritis

85%

6

how sensitive is anti CCP for rheumatoid arthritis

95%

7

what are the seronegative spondyloarthropathies also called

rheumatoid variants

8

what are the clinical features of AS

spine and SI joints
extremities - 30%
males common

9

what are the lab features of AS

ESR increase 90%
HLA-B27 - not diagnostic

10

what are the clinical features of psoriatic arthritis

DIP joints
spine 20%

11

what percent of psoriatics develop arthritis

10%

12

what are the clinical features of reiters syndrome

arthritis
urethritis - non GC
conjuctivitis
iritis
mucocutaneous oral ulcers

13

what are the clinical features of arthritis associated with IBD

20% of IBD develop migratory, lower extremity, peripheral joint disease

sacroilitis 15%

iritis is common

spondylitis 5%

14

iritis is common in what 2 arthritidies

reiters syndrome
and
enteropathic/IBD

15

enteropathic/IBD arthritis commonly affects what joints

knee and ankle

16

acute rheumatic fever is caused by what

group a beta hemolytic strep

hypersensitivity reaction after infection of GABHS

17

what are the aggregations of histiocytes called in acute rheumatic fever

aschoff bodies

18

what are the clinical features of acute rheumatic fever

fever
migratory arthritis
cardiac damage
renal damage

19

what is the ASO titer used for

what are the values that may indicate or that are diagnostic of the disease

GABHS

>200 = indicative of recent strep infection

>500 = diagnostic for disease

20

what are the lab values of acute rheumatic fever

ASO titer
>200 - indicates strep
>500 - diagnostic

ESR elevated

21

what is a extremely painful and immobilizing form of arthritis

gout

22

what are the clinical features of gout

painful
monoarticular
affects big toe

23

what part of the body does gout rarely affect

spine

24

what causes gout

uric acid accumulation from purine synthesis

increased intake of purines - doesnt cause gout - may worsen tho

decreased excretion of uric acid

increased production of uric acid

25

decreased secretion of uric acid can be caused by what

renal insufficiency
thiazide diuretics
ketoacidosis
alcoholism
hypothyroidism

26

increased production of uric acid can be caused by what

hypermetabolic syndromes
myeloproliferative syndrome
leukemia
polycythemia vera
malignancy
chemo or radiation
hemolytic anemia
diabetes
sarcoidosis

27

what are a defined group of diseases exhibiting necrosis of collageneous tissue and inflammatory arterial disease

collagen vascular disease

28

what are the clinical features of collagen vascular diseases

myalgia
fatigue
headache
stiffness

29

what are examples of diseases in the group of collagen vascular diseases

progressive systemic sclerosis (PSS)
mixed connective tissues disease (MCTD)
sjorgens syndrome
temporal arteritis
SLE

30

what does ANA indicate

any autoimmune disorders

SLE, MTCD, PSS, RA, scleroderma, sjorgens