Protein and Myocardial Infarction Flashcards Preview

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Flashcards in Protein and Myocardial Infarction Deck (29)
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1

what is the majority of protein in blood

albumin 60%
globulin 40%

2

what is albumin made up of

prealbumin and albumin

3

where is albumin made

liver

4

how is albumin a measure of liver function

diseased liver cells lose ability to create albumin so its decreased in liver damage

5

what is the main purpose of albumin

maintain osmotic pressure and transport substances - drugs, hormones, enzymes

6

does albumin increase or decrease the solubility of materials in blood

increases

7

where are globulins made

most are made in the reticular endothelial system

RE system and liver

8

what are globulins divided into

alpha globulins
beta globulins
gammaglobulins

9

what are the majority of alpha globulins

what type of protein are they

when are they elevated

alpha 1 anti-trypsin 90%

acute phase protein

inflammation, malignancy, infection

10

an absence of alpha globulins indicates what

absence of alpha 1 antitrypsin causes emphysema

11

what are the alpha globulin proteins

besides alpha 1 antitrypsin, the rest of the alpha globulins are thyroid or cortisol binding proteins

haptoglobulin
prothrmobin
ceruloplasmin
cholinesterase

12

what are the beta 1 globulins

what are the beta 2 globulins

beta 1 - lipoproteins, transferrin, plasminogen, compliment

beta 2 - fibrinogen

13

what are the gamma globulins

immune globulins
antibodies

14

what is serum protein electrophoresis

separates the components of the serum

electric current passed through sample and the charged proteins migrate into a pattern descriptive of certain diseases

15

what can be divided and fractioned out by electrophoresis if they is a spike

what does the pathologist due if they read a spike

what do these spikes mean

immunoglobin

classify it as monoclonal or polyclonal

monoclonal - multiple myeloma and waldenstroms macroglobulinemia

polyclonal - cirrhosis, nephrotic syndrome, chronic or acute inflammation

16

__% of MIs shows unequivocal evidence on ECG

__% of MIs show non specific changes

50%

30%

17

what is the usual presentation of MI

symptoms and evidence of tissue damage

18

patients with MI may exhibit a ___ within __ hrs of chest pain and may last a week or two

__ elevates and stays elevated for __

WBC increase
Mostly PMN
12-24 hrs

ESR --> 3-4 weeks

19

when does AST elevate in MI

elevates first 12 hrs
peaks at 24 hrs
normal in a week

20

when does LDH elevate in MI

elevates in 24-48 hrs
peaks at 48-72 hrs
normal in 5-10 days

21

where is CK found

cardiac muscle
skeletal muscle
brain

22

why is CK iso enzyme used

used to DDx cardiac from other sources of AST or LDH

23

CKBB or CK1 is found where

brain and lung

24

CKMB or CK2 is found where

cardiac muscle

25

when does CKMB elevate in MI

elevates 3-6 hrs
peaking 24 hrs
normal 48 hrs

26

CKMM or CK3 is found where

skeletal muscle mostly
little in cardiac muscle

27

Troponin T elevates when

how does it compare to CKMB

elevates 4-6 hrs

stays longer than CKMB

28

Troponin I elevates when

may elevate sooner than Troponin T
stays for 3-4 days

29

what is brain natiuretic peptide produced

when does it increase

produced by the heart

increased cardiac workload and causes kidney to secrete Na