CARDIO common drugs Flashcards Preview

Resp > CARDIO common drugs > Flashcards

Flashcards in CARDIO common drugs Deck (85)
Loading flashcards...
1

what are the anticholesterol drugs?

statins eg simvastatin
fibrates eg bezafibrate
PCSK 9 inhibitors

2

how do statins work?

- they block HMG CoA reductase which is the rate limiting enzyme in hepatic cholesterol synthesis

3

what are the side effects of statins?

- myopathy
- rhabdomyolysis

4

who should recieve a statin?

- anyone with a CVD
- diabetes
- hypercholesterolaemia

5

when should statins be taken?

orally at night as this is when cholesterol synthesis takes place

6

how do fibrates work?

they are an agonist of PPAR-alpha, therefore increases lipoprotein lipase expression

7

what are the side effects of fibrates?

- myositis = inflammation of muscles
- pruritus = itchy skin
- cholestasis

8

what are the antihypertensive drugs?

- thiazide diuretics
- beta blockers
- mineralcorticosteroids
- vasodilators eg calcium antagonists, alpha blockers, ACEi, ARBs

9

give an example of a thiazide diuretic?

eg bendrofluazide

10

how do thiazide diuretics work?

- they inhibit sodium reabsorption by blocking the thiazide-sensitive N+-Cl_ symporter at the beginning of the distal convoluted tubule

11

what are the side effects of thiazide diruetics?

- hyperglycaemia
- increased uric acid
- impotence
- gout
- dehydration
- hypokalaemia

12

what are thiazide diruetics used for?

- hypertension

13

what is an example of a loop diuretic?

eg furosemide

14

how do loop diuretics work?

- by inhibiting NaCl reabsorption in the thick ascending loop of henle
- they inhibit the costransport of NaKCl

15

what are loop diuretics used for?

- heart failure
- resistant hypertension

16

what are the side effects of loop diruetics?

- hyperglycaemia
- increased uric acid
- impotence
- hypotension
- renal impairment
- hypokalaemia
- deafness (over use of drug)

17

what are cardioselective beta blockers? give an example.

they only block b1
eg atenolol, bisoprolol

18

what are cardioselective beta blockers used for?

- angina
- acute coronary syndrome
- MI

19

what are non-selective beta blockers? give an example

- block b1 and b2
- eg propranolol

20

what are non-selective beta blockers used for?

- migraine

21

what are the side effects of beta blockers?

- asthma
- tired
- worsened heart failure symptoms
- cold peripheries

22

what are dihydropyridines used for? give an example

eg amoldipine
- used in hypertension
- angina
- raynauds

23

what are the side effects of dihydropyridines?

ankle oedema

24

what are rate limiting calcium antagonists used for?

- hypertension
- angina

25

give an example of a rate limiting calcium antagnosits?

- verapamil

26

when should you avoid using a rate limiting calcium antagnosist and why?

- when given with a betablocker
- it may cause heart block

27

how do angiotensin converting enzymes work?

by blocking angiotensin 1 from becoming angiotensin 2

28

give an example of ACEi?

- lisinopril

29

when are ACEis used?

- hypertension
- heart failure

30

what are the side effects of ACEis?

- dry cough
- renal dysfunction
- very steep drop in blood pressure for first dose, eg in patients who are on diuretics because they are Na+ depleted