Flashcards in Hepatitis B Deck (3):
How is Hep B managed?
- Pegylated interferon-alpha used to be the only treatment available. It reduces viral replication in up to 30% of chronic carriers. A better response is predicted by being female,
How are people immunised against Hep B?
- Course of 3 injections of HBsAg
- One off booster at +5yrs
- at risk groups who need vaccination: health workers, sex workers, IV drug users, relatives, regular receivers of blood transfusions, CKD patients, chronic liver disease patients, prisoners
- 10-15% respond poorly to immunisation. Reasons include immunosuppression, >40yrs, smoker, obese, alcohol excess
- those at risk of exposure should have their HBsAb tested:
>100 is good, no further testing needed
10-100 average, requires further single dose of HBsAg