Pharmacokinetics - Drug Elimination

Question 1

It takes roughly _____ half-lives for a drug to be eliminated.

Answer 1

four to five

Question 2

Clearance (Cl) is equal to ____x ____.

Answer 2

Vd; Ke

Question 3

The rearranged formula for first-order kinetics is ________.

Answer 3

ln (Cp) = - Ke (t) + ln (Cpo)

Question 4

Which method of drug interaction is faster, induction or inhibition?

Answer 4

Inhibition (because it directly binds to the enzyme)

Question 5

Drugs that depend strongly on hepatic clearance can be affected by three things. What are they?

Answer 5

Blood flow to the liver, intrinsic hepatic activity (such as enzyme function in the presence of inducers or inhibitors), and amount of protein bound to the drug.

Question 6

What is the equation for fold-fluctuations?

Answer 6

2^n (where n equals the amount of half-lives in the dosing interval)

Question 7

Loading Dose (LD) = _______.

Answer 7

Desired Cpo (Cpo) x Volume of Distribution (Vd)