EPINEPHRINE (Adrenalin®, EpiPen®, EpiPen® Jr.) Flashcards

1
Q

Generic/Trade Name

EPINEPHRINE

A

Adrenalin®, EpiPen®, EpiPen® Jr.

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2
Q

Generic/Trade Name

Adrenalin®, EpiPen®, EpiPen® Jr.

A

EPINEPHRINE

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3
Q

EPINEPHRINE (Adrenalin®, EpiPen®, EpiPen® Jr.)

Drug Classification:

A
  • Sympathomimetic
  • Sympathetic agonist
  • Catecholamine
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4
Q

EPINEPHRINE (Adrenalin®, EpiPen®, EpiPen® Jr.)

Mechanism of Action:

A
  • α1 agonist ⇒peripheral vasoconstriction, increases SVR and BP
  • β1 agonist ⇒positive inotropy, chronotropy, dromotropy
  • β2 agonist ⇒bronchodilation
  • Blocks destruction of MAST cells (which release Histamine) in anaphylaxis
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5
Q

EPINEPHRINE (Adrenalin®, EpiPen®, EpiPen® Jr.)

Pharmacokinetics

A

Onset of Action < 2 minutes IV, 3-10 minutes IM

Peak Effects < 5 minutes IV, 20 minutes IM

Duration of Effect = 5-10 minutes IV, 20-30 minutes IM

Half-Life = 5 minutes IV

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6
Q

EPINEPHRINE (Adrenalin®, EpiPen®, EpiPen® Jr.)

Indications/Field Use:

A
  • Cardiac arrest
  • Anaphylaxis/Severe reactive airway disease/asthma
  • Symptomatic bradycardia/hypotension
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7
Q

EPINEPHRINE (Adrenalin®, EpiPen®, EpiPen® Jr.)

Contraindications:

A
  • HTN and tachydysrhythmias
  • use caution with pregnancy and CAD
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8
Q

EPINEPHRINE (Adrenalin®, EpiPen®, EpiPen® Jr.)

Side Effects/Adverse Reactions:

A
  • Anxiety
  • HA,
  • dysrhythmias,
  • tremulousness,
  • dizziness,
  • N+V

*Leads to increased myocardial oxygen demand*

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9
Q

EPINEPHRINE (Adrenalin®, EpiPen®, EpiPen® Jr.)

ADULT DOSE:

A
  • Cardiac arrest : 0.5-1mg IV, IO [1:10,000] q 3-5 min
  • Bradycardia/Hypotension : 2-10 μg/min
  • Anaphylaxis/Asthma : 0.3-0.5mg IM, SC [1:1000], then 0.1mg [1:10,000]
    slow IV, IO over 3 minutes
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10
Q

EPINEPHRINE (Adrenalin®, EpiPen®, EpiPen® Jr.)

PEDI DOSE:

A
  • Cardiac arrest: 0.01mg/kg IV, IO [1:10,000] q 3-5 min
  • Anaphylaxis/Asthma : 0.01mg/kg IM,SC [1:1000], then 0.01mg/kg [1:10,000], max dose 0.3mg, slow IV,IO
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11
Q

EPINEPHRINE (Adrenalin®, EpiPen®, EpiPen® Jr.)

Precautions:

A

Should be protected from light

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12
Q

EPINEPHRINE (Adrenalin®, EpiPen®, EpiPen® Jr.)

Drug-Drug Interactions:

A
  • pH dependent,
  • deactivated by alkaline solutions;
  • effect intensified w/ Pt’s taking antidepressants,
  • reacts with CaCl2 and NaHCO3 to form PPT (in IV tubing)
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