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Flashcards in Hematologic/Oncologic/Immunologic Disorders Deck (48)
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1

Baseline management of all neonates with ABO incompatibility includes:
a) phototherapy
b) serial monitoring of bilirubin and hemoglobin levels
c) exchange transfusion
d) simple transfusion of packed RBCs

b) serial monitoring of bilirubin and hemoglobin levels

2

Which of the following is not associated with Rh incompatibility?
a) Mother Rh negative, baby born Rh positive
b) Mother Rh positive, baby Rh negative
c) More severe in subsequent sensitized pregnancies
d) Hemolysis may occur up to 6 weeks or more

b) Mother Rh positive, baby Rh negative

3

Clinical jaundice of the distal extremities would be noted at a bilirubin level of:
a) 15 mg/dL

d) > 15 mg/dL

4

Beta-chain synthesis is absent in:
a) Beta-thalassemia minor
b) Beta-thalassemia intermedia
c) Beta-thalassemia major
d) Alpha-thalassemia trait

c) Beta-thalassemia major

5

Which of the following are most often associated with hemoglobin C?
a) growth retardation
b) hepatosplenomegaly
c) usually asymptomatic
d) frontal bossing

c) usually asymptomatic

Symptoms include anemia, occasional jaundice, and occasional enlargement of the spleen.

6

Diagnostic findings consistent with beta-thalassemia are:
a) hemoglobin normal
b) reticulocytes normal
c) Hgb A2

d) hypochromia, microcytosis

7

Asplenic children are at increased risk for which of the following?
a) bacterial infections
b) fungal infections
c) viral infections
d) parasites

a) bacterial infections

Particularly streptococcus pneumoniae.

8

Which of the following is not considered preventive management for iron deficiency anemia?
a) iron fortified cereal from 6 to 12 months of age
b) iron fortified formula until 6 months of age
c) no cow's milk until 1 year of age
d) if breastfeeding supplemental iron drops or iron fortified cereal by 4-5 months of age.

b) iron fortified formula until 6 months of age

9

The expected clinical severity of hemoglobin sickle C disease (Hgb SC) is:
a) asymptomatic
b) marked to moderate
c) mild to moderate
d) severe

c) mild to moderate

10

The expected hemoglobin range for sickle cell anemia is:
a) 6.5-9.5 g/dL
b) 13.5-16.5 g/dL
c) 8.5-12.5 g/dL
d) 9.5-13.5 g/dL

a) 6.5-9.5 g/dL

11

Prophylactic penicillin should be initiated in children with sickle cell anemia by:
a) 3 years of age
b) 12 months of age
c) 2-3 months of age
d) 9 months of age

c) 2-3 months of age

12

Hemolysis does not contribute to which of the problems associated with sickle cell disease?
a) chronic anemia
b) splenic sequestration
c) aplastic crisis
d) delayed growth

b) splenic sequestration

13

The following blood lead level is not considered lead poisoning:
a) 15
d) >25

a)

14

Which of the following is not a precipitating factor for hemolysis in G-6-PD deficiency?
a) drugs
b) exposure to extreme temperatures
c) ingestion of fava beans
d) infection

b) exposure to extreme temperatures

15

What percent of factor VIII/IX is associated with severe hemophilia A and B?
a) >1
b) 1-5
c) 5-25
d) 30-50

a) >1

16

What type of hemorrhage would be expected with severe factor VIII deficiency?
a) severe hemorrhage following moderate to severe trauma
b) gross bleeding following mild to moderate trauma
c) gynecologic hemorrhage
d) spontaneous hemarthrosis

d) spontaneous hemarthrosis

17

Which of the following is the most common type of congenital bleeding disorder?
a) hemophilia A
b) hemophilia B
c) von Willebrand disease
d) idiopathic thrombocytopenia purpura

c) von Willebrand disease

18

Which of the following medications should be avoided in a child with ITP?
a) decongestants
b) aspirin
c) acetaminophen
d) sulfa drugs

b) aspirin

19

The following test is required to diagnose leukemia:
a) CBC with differential
b) bone marrow aspiration/biopsy
c) chest radiograph
d) biopsy of an enlarged lymph node

b) bone marrow aspiration/biopsy

20

Which of the following is not included as part of the initial therapy for ALL?
a) chemotherapy
b) radiation therapy
c) bone marrow transplant
d) intrathecal chemotherapy

c) bone marrow transplant

21

Which malignancy is associated with genitourinary anomalies?
a) acute lymphocytic leukemia
b) chronic myleogenous leukemia
c) osteosarcoma
d) Wilms tumor

d) Wilms tumor

22

Which of the following statements are true about immunizations during treatment of childhood cancer?
a) children continue to receive immunizations as usual
b) immunizations are not given during active chemotherapy
c) only live vaccines are held during active chemotherapy
d) no family member should be immunized while the child is receiving chemotherapy

b) immunizations are not given during active chemotherapy

23

The peak incidence of osteosarcoma is:
a) 4-7 years of age
b) 8-11 years of age
c) 12-14 years of age
d) 15-19 years of age

d) 15-19 years of age

24

The following type of infection is not associated with hypogammaglobulinemia:
a) sinusitis
b) pneumonia
c) UTI
d) cellulitis

c) UTI

25

The following diagnostic finding is consistent with X-linked agammaglobulinemia:
a) IgG normal
b) B cells decreased
c) T cells decreased
d) IgA normal

b) B cells decreased

26

The following is not a characteristic feature of DiGeorge syndrome:
a) hypertelorism (wide spaced eyes)
b) cleft palate
c) cardiac defects
d) frontal bossing

d) frontal bossing

27

The following diagnostic finding is consistent with Wiskott-Aldrich syndrome:
a) IgG normal
b) IgA decreased
c) IgM increased
d) B cells decreased

a) IgG normal

IgE levels are elevated; T & B lymphocyte function are abnormal.

28

Management of a patient with splenectomy does not include:
a) pneumococcal vaccine at least 2 weeks prior to surgery
b) prophylactic penicillin
c) blood culture and parenteral antibiotics for febrile illnesses
d) treating fever with antipyretics only and observing for resolution

d) treating fever with antipyretics only and observing for resolution

29

A 3 yo boy with known G6PD deficiency has acute purulent OM. Which of the following drugs should not be used for his treatment?
a) amoxicillin
b) augmentin
c) erythromycin
d) bactrim

d) bactrim

Sulfa drugs precipitate hemolysis in patients with G6PD.

30

A 2 yo is brought in for complaints of anorexia and irritability for the past several weeks. You note that she is afebrile and appears pale. Based on the s/s which initial action is appropriate?
a) ask for a description of her diet including the specific foods she was eating prior to the onset of symptoms
b) prescribe supplemental iron therapy to be given TID
c) order lab work to assess RBC count and indices
d) refer to a pediatrician for further evaluation

a) ask for a description of her diet including the specific foods she was eating prior to the onset of symptoms

Asking about diet prior to illness will help determine whether this patient was receiving enough iron in her diet and can help determine a differential diagnosis.