SM_257a: Papulosquamos Disorders Flashcards Preview

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Flashcards in SM_257a: Papulosquamos Disorders Deck (22)
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1

Psoriasis is an ____ skin disease that consists of ____ and has a predilection for the ____ and ____

Psoriasis is an inflammatory skin disease that consists of thick well defined scaly plaques (raised) with silvery scale and has a predilection for the elbows and knees

2

Thick scaly rash with silvery scale on elbows and knees is ____

Thick scaly rash with silvery scale on elbows and knees is psoriasis

3

Psoriasis can be ____ or cover  ____

Psoriasis can be localized or cover the entire body

 

  • Erythrodermic psoriasis: entire body red and scaly
  • Palmoplantar psoriasis: on palms and soles
  • Can involve scalp
  • Can involve nails

4

Psoriasis affecting the nails includes ____ and ____

Psoriasis affecting the nails includes pits and onycholoysis

 

  • Onycholoysis: yellow discoloration caused by lifting of nail plate from the bed

5

Bright red rash with silvery scalp and abnormal looking nails is ____

Bright red rash with silvery scalp and abnormal looking nails is psoriasis

6

Psoriasis histology includes ____ caused by ____

Psoriasis histology includes elongated thickened epidermis caused by overly rapid production of keratinocytes

 

(migration to stratum corneum in 3-7 days vs 28 days, also thick stratum corneum and proliferation and dilation of blood vessels near surface)

7

Psoriasis is a ____ condition that has onset at ____ and involves a ____ factor

Psoriasis is a chronic condition that has onset at any age of life and involves a genetic factor

 

(patients with psoriasis sometimes have relatives with disease but not always)

8

Psoriasis is an ____ mediated condition with _____ driven by a complex cascade of inflammatory mediators

Psoriasis is an immune mediated condition with hyperproliferation driven by a complex cascade of inflammatory mediators

9

____ and overexpression of cytokines ____, ____, and ____ play a pivotal rolate in psoriasis

T cells and overexpression of cytokines TNF-alpha, IL-17, and IL-23 play a pivotal rolate in psoriasis

10

Psoriasis triggers include ____, ____, ____, and ____

Psoriasis triggers include Streptococci (Strep pharyngitis), stress, trauma (skin injury), and drugs

 

(Guttate psoriasis is an example of an environmental trigger)

11

Describe psoriatic arthritis

Psoriathic arthritis

  • 1--30% of patients with psoriasis
  • Inflammatory immune mediated arthritis
  • May lead to destructive, disabling arthritis
  • Signs and symptoms: morning stiffness (lower back, neck, hands, feet) that improves after 30 min - 1 hour after waking, dactylitis (sausage digits), and enthesitis

12

Localized psoriasis is treated mainly with ____

Localized psoriasis is treated mainly with high potency topical steroids (clobetasol, triamcinolone)

13

Widespread psoriasis is treated with ____ that includes ____, ____, and ____

Widespread psoriasis is treated with targeted therapy (large molecule drugs targeting specific cytokines that drive psoriasis) that includes TNF-alpha blockers, IL-23 blockers, and IL-17 blockers

 

(most superior skin clearance)

14

Widespread psoriasis treatment includes ____, ____, and ____

Widespread psoriasis treatment includes TNF-alpha blockers, IL-23 blockers, and IL-17 blockers

 

(targeted therapy: large molecule drugs targeting specific cytokines that drive psoriasis: most superior skin clearance)

15

Seborrheic dermatitis is ____

Seborrheic dermatitis is redness and thin yellow waxy flaking around the nose (nasolabial folds), eyebrows, beard area, ears, hairline, and scalp

16

17

Seborrheic dermatitis may be related to the presence of ____

Seborrheic dermatitis may be related to the presence of yeast (Pityrosporum ovale)

18

Seborrheic dermatitis treatment includes ____ and ____

Seborrheic dermatitis treatment includes antifungal creams and mild topical steroid

19

Pityriasis rosea is an ____, an ____ process, and often begins with ____

Pityriasis rosea is an oval salmon colored thin macule or patches with thin scale mostly affecting the trunk, an acute self resolving process (3-8 weeks), and often begins with a single larger initial patch (herald patch) before other macules appear

20

Herald patch and acute self resolving refer to ____

Herald patch and acute self resolving refer to pityriasis rosea

21

____ pattern on the back refers to pityriasis rosea

Christmas tree pattern on the back refers to pityriasis rosea

22

____ may cause pityriasis rosea

Possible reactivation of HHV-6 or HHV-7 may cause pityriasis rosea

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