SM_267a: Viral Infections / Exanthems Flashcards Preview

MSK/Derm > SM_267a: Viral Infections / Exanthems > Flashcards

Flashcards in SM_267a: Viral Infections / Exanthems Deck (49)
Loading flashcards...
1

Herpes simplex virus is a ____ with ____

Herpes simplex virus is a herpesvirus with dsDNA

2

HSV presents as ____

HSV presents as cluster of grouped vesicles on an erythematous base

3

HSV can remain ____ and ____ periodically

HSV can remain dormant in local nerve ganglia and reactivate periodically

4

Describe clinical diagnosis of HSV

HSV

  • Grouped (clustered) vesicles on erythematous base: can be painful
  • Tingling, itching, burning on the skin (before visible vesicles) -> red papules (1 day later) -> vesicles -> crusted lesions (lasts 1-2 weeks, may be recurrent in nature)
  • UVB radiation is common trigger of orolabial HSV

5

____ is common trigger of orolabial HSV

UVB radiation is common trigger of orolabial HSV

6

____ are found on Tzanck smear of HSV

Multinucleated giant cells are found on Tzanck smear of HSV

 

(abnormal cell division in cells caused by HSV)

7

Eczema herpeticum is ____

Eczema herpeticum is disseminated HSV lesions in patient with widespread eczema (atopic dermatitis)

 

(sudden onset of widespread small umbilicated vesicles that turn into small round erosions in a patient with active atopic dermatitis)

8

____ caused by ____ is sudden onset of widespread small umbilicated vesicles that turn into small round erosions in a patient with active atopic dermatitis

Eczema herpeticum caused by HSV is sudden onset of widespread small umbilicated vesicles that turn into small round erosions in a patient with active atopic dermatitis

9

Varicella zoster virus belongs to the ____ family

Varicella zoster virus belongs to the herpes family

 

(dsDNA)

10

____ infection of VZV leads to clinical presentation known as chicken pox

Primary infection of VZV leads to clinical presentation known as chicken pox

11

Varicella zoster virus is transmitted by ____ or ____

Varicella zoster virus is transmitted by respiratory droplet or direct contact

12

Varicella zoster virus is contagious beginning _____ and lasting _____

Varicella zoster virus is contagious beginning 24 hours before eruption appears on skin and lasting until lesions have crusted

13

Describe clinical presentation of chicken pox

Chicken pox clinical presentation

  • Multiple lesions on skin at various stages: faint red macules -> vesicle -> crusted papule
  • Vesicle on an erythematous base: "dewdrop on a rose petal"
  • Multinucleated giant cells with Tzanck smear
  • Systemic complications of pneumonia and encephalitis

14

"Dewdrop on rose petal" refers to ____ caused by ____

"Dewdrop on rose petal" refers to chicken pox caused by Varicella Zoster Virus

 

 

(vesicle on erythematous base)

15

____ are found on Tzanck smear of chicken pox (Varicella Zoster Virus)

Multinucleated giant cells are found on Tzanck smear of chicken pox (Varicella Zoster Virus)

16

Chicken pox vaccine is ____

Chicken pox vaccine is live attenuated

 

(2 doses)

17

Describe effect of chicken pox on special populations

Chicken pox (VZV) in special populations

  • Pregnant women and neonates: maternal infection during first 20 weeks may result in syndrome of congenital malformation to fetus or spontaneous abortion
  • Immunocompromised patient: can be fatal in patients with cell-mediated immunity, varicella pneumonia / hepatitis / encephalitis

18

Shingles is _____

Shingles is reactivation of dormant Varicella Zoster Virus from sensory dorsal root ganglion

19

Shingles has ____ distribution of crop of vesicles and pustules on an erythematous base

Shingles has dermatomal distribution of crop of vesicles and pustules on an erythematous base

 

(unilateral)

 

(if disseminated look for immunosuppression - check HIV status)

20

____ are found on Tzanck smear of shingles (Varicella Zoster Virus)

Multinucleated giant cells are found on Tzanck smear of shingles (Varicella Zoster Virus)

21

Describe clinical clues for shingles

Shingles clinical clues

  • Preceded by one to several days of numbness, tingling, or pain in affected area prior to onset of rash
  • Papules -> vesicles -> pustules in a background of erythema in a dermatomal distribution

22

Describe complications of shingles

Shingles complications

  • Post-herpetic neuralgia: burning or deep aching pain or shooting pain that may persist for weeks after the skin lesions have healed
  • Ramsay Hunt syndrome: VZV infection of the geniculate ganglion (CN VII - facial nerve), involvement of external ear and/or tympanic membrane, and facial paralysis (ipsilateral)

23

Ramsay Hunt syndrome is ___ infection of the ___ leading to ___ and with involvement of ___

Ramsay Hunt syndrome is VZV infection of the geniculate ganglion (CN VII - facial nerve) leading to ipsilateral facial paralysis and with involvement of external ear and / or tympanic membrane

24

Shinges vaccine (one dose) is recommended for ___

Shinges vaccine (one dose) is recommended for peopled aged ≥ 60

 

(even if they had a bout of shingles)

25

Kaposi sarcoma occurs in setting of ____, results from ____, and presents as ____

Kaposi sarcoma occurs in setting of AIDS / other immunosuppression, results from HHV-8, and presents as brown / dark red violaceous lesions

 

(lesions look vascular)

26

Pityriasis rosea is a ____ rash that presents as ____

Pityriasis rosea is a post-viral rash that presents as a large oval patch (Herald patch) followed by oval slightly scaly patches scattered on a trunk (sometimes in Christmas tree distribution)

27

Christmas tree distribution refers to ____

Christmas tree distribution refers to pityriasis rosea

28

Pityriasis rosea differential diagnosis includes ____

Pityriasis rosea differential diagnosis includes secondary syphilis

 

(pityriasis rosea will self-resolve in 3-8 weeks)

29

Molluscum contagiosum is a ____ with ____ and an ____

Molluscum contagiosum is a poxvirus with linear double stranded DNA and an envelope

30

Molluscum contagiosum affects mainly ___, ___, and ___

Molluscum contagiosum affects mainly children, sexually active adults, and individuals with impaired cellular immunity

Decks in MSK/Derm Class (49):