SM_266a: Autoimmune Systemic Diseases Flashcards Preview

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Flashcards in SM_266a: Autoimmune Systemic Diseases Deck (35)
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1

Vitiligo is ____

Vitiligo is an acquired autoimmune disorder of the skin in which destruction of melanocytes leads to well-demarcated patches of depigmentation

 

(often devastating for those affected)

2

Vitiligo is characterized by ____

Vitiligo is characterized by well demarcated areas of pigmentation

3

Vitiligo may be associated with ____

Vitiligo may be associated with other autoimmune conditions such as thyroid dysfunction, alopecia areata, and diabetes mellitus

 

(consider checking TSH)

4

Consider checking ____ in patients with vitiligo

Consider checking TSH in patients with vitiligo

5

Vitiligo is treated with ____, ____, ____, ____, or ____

Vitiligo is treated with phototherapy (light therapy), topical steroids, topical immunosuppressants (e.g. Tacrolimus), laser, or depigmentation

6

Alopecia areata is ____

Alopecia areata is an acquired autoimmune disorder targeting hair follicle structures resulting in recurrent patches of non-scarring alopecia

 

(often associated with significant psychosocial and emotional distress)

7

Alopecia areata most commonly presents as ____

Alopecia areata most commonly presents as well demarcated round patches of alopecia

8

Alopecia areata has possible association with ____

Alopecia areata has possible association with other autoimmune conditions such as thyroid disease, vitiligo, and diabetes

 

(check TSH)

9

Check ____ in patients with alopecia areata

Check TSH in patients with alopecia areata

10

Acrodermatitis enteropathica is a ____ deficiency and presents as ____

Acrodermatitis enteropathica is a zinc deficiency and presents as perioral / perianal erosive scaly rash

11

Acrodermatitis enteropathica appears in ____ if genetic

Acrodermatitis enteropathica appears in babies days to weeks after birth or after weaning from breast feeding if genetic

12

Scurvy is ____ deficiency and presents as ____

Scurvy is ascorbic acid deficiency and presents as bleeding, gingivae, petechiae, ecchymoses, follicular hyperkeratosis, and corkscrew hairs

13

Lynch syndrome (hereditary non-polyposis colorectal cancer) is associated with ____, ____, ____, and ____ carcinomas and ____ adenoma/carcinoma in Muir-Torre

Lynch syndrome (hereditary non-polyposis colorectal cancer) is associated with colorectal, endometrial, ovarian, and gatric carcinomas and sebaceous adenoma/carcinoma in Muir-Torre

14

Sweet's syndrome (acute febrile neutrophilic dermatosis) is characterized by ____

Sweet's syndrome (acute febrile neutrophilic dermatosis) is characterized by neutrophilic infiltrate

15

Sweet's syndrome (acute febrile neutrophilic dermatosis) involves ____ and ____ and is treated with ____

Sweet's syndrome (acute febrile neutrophilic dermatosis) involves fever and general malaise and is treated with oral prednisone

16

Sweet's syndrome (acute febrile neutrophilic dermatosis) is associated with ____, ____, ____ and ____

Sweet's syndrome (acute febrile neutrophilic dermatosis) is associated with malignancy (especially AML), inflammatory bowel disease, drugs (G-CSF), pregnancy, and infections (Streptococcus URI, Yersiniosis)

17

Cirrhosis involves ____ and ____

Cirrhosis involves dilated abdominal veins (caput medusae) and spider angiomas

18

Lichen planus is an ____ that occurs after ____ and presents as ____

Lichen planus is an idiopathic inflammatory skin disease that occurs after Hepatitis C presents as flat topped violaceous papules

19

Renal disease includes ____ and ____

Renal disease includes pruritis and calciphylaxis

20

Describe pruritis

Pruritis

  • Possibly related to increase in tissue mast cells
  • Localized or generalized
  • Worse with hemodialysis
  • Treatment: emollients, UV light, gabapentin, anti-histamines

(renal disease)

21

Calciphylaxis is ____ that presents as ____

Calciphylaxis is progressive vascular calcification of the skin and soft tissue that presents as violaceous reticulated patches

22

Calciphylaxis progresses from ___ to ___ to ___

Calciphylaxis progresses from bullae to tissue necrosis to ulceration

23

Calciphylaxis is ____ and affects ____ areas of the body

Calciphylaxis is extremely painful and affects painful areas of the body

24

Describe sarcoidosis

Sarcoidosis

  • Lupus pernio: papulonodules and plaques involving areas affected by cold - nose, ears, cheeks
  • Lofgren's syndrome: erythema nodosum + hilar adenopathy + fever + polyarthritis + acute iritis
  • Can affect virtually any organ system

25

Lupus pernio occurs in ____, presents as ____, and has a strong association with ____ disease

Lupus pernio occurs in sarcoidosis, presents as papulonodules and plaques involving areas affected by cold (nose, ears, cheeks), and has a strong association with chronic lung and upper respiratory tract disease

26

Lofgren's syndrome occurs in ____ and involves ____, ____, ____, ____, and ____

Lofgren's syndrome occurs in sarcoidosis and involves erythema nodosum, hilar adenopathy, fever, polyarthritis, and acute iritis

27

Addison's disease is ____

Addison's disease is diffuse hyperpigmentation from activity of melanocyte-stimulating hormone

 

(endocrine disorder)

28

Diabetes mellitus manifests as ____ on the skin which is ____

Diabetes mellitus manifests as acanthosis nigricans on the skin which is velvety, hyperpigmented plaques in flexural surfaces

 

(most commonly occurs in overweight persons with insulin resistance)

29

Acanthosis nigricans in diabetes mellitus most commonly occurs in ____ people with ____

Acanthosis nigricans in diabetes mellitus most commonly occurs in overweight people with insulin resistance

 

 

(velvety, hyperpigmented plaques in flexural surfaces)

30

Describe pyoderma gangrenosum

Pyoderma gangrenosum

  • Ulcer with necrotic, undermined borders
  • Painful, typically lower extremities
  • Associated with inflammatory bowel disease, arthritis, monoclonal gammopathy, CML
  • Treatment is systemic steroids, TNF inhibitors, rituximab

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