Flashcards in Anticoagulants and antiplatelets Deck (9):
Main differences between unfractionated heparin and LMWH?
IV, short duration of action, Activates antithrombin III, inhibits thrombin, factors Xa, IXa, Xia and XIIa
Monitor with APTT
LMWH: sub cut, long action, activates anihrombin III, inhibits factor Xa, monitor with anti-factor Xa. less SE
What is unfractionated heparin used for?
In situations with high risk of bleeding (short acting, can terminate)
When is LMWH used?
1st line for treatment and prophylaxis of VTE and treatment of MI
Can you reverse LMWH and unfractionated heparin?
but only partially reverses LMWH
What should be done in major bleeding when a pt is on warfarin?
Vit K1 (phytomenadione) IV 5mg
2500U dried prothrombin complex
What does dried prothrombin complex contain?
X, IX, VII, II
What fruit interacts with warfarin?
How can you assess anticoagulant effect when a pt on rivoroxaban presents with haemorrhage?
INR and APTT are unreliable
Symptoms (eg number of coffee ground vomits) and Hb can be monitored instead