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Flashcards in Anticoagulants and antiplatelets Deck (9):
1

Main differences between unfractionated heparin and LMWH?

Unfractionated:
IV, short duration of action, Activates antithrombin III, inhibits thrombin, factors Xa, IXa, Xia and XIIa
Monitor with APTT
LMWH: sub cut, long action, activates anihrombin III, inhibits factor Xa, monitor with anti-factor Xa. less SE

2

What is unfractionated heparin used for?

In situations with high risk of bleeding (short acting, can terminate)

3

When is LMWH used?

1st line for treatment and prophylaxis of VTE and treatment of MI

4

Can you reverse LMWH and unfractionated heparin?

Yes, PROTAMINE
but only partially reverses LMWH

5

What should be done in major bleeding when a pt is on warfarin?

Vit K1 (phytomenadione) IV 5mg
2500U dried prothrombin complex

6

What does dried prothrombin complex contain?

1972
X, IX, VII, II

7

What fruit interacts with warfarin?

Cranberry juice

8

How can you assess anticoagulant effect when a pt on rivoroxaban presents with haemorrhage?

INR and APTT are unreliable
Symptoms (eg number of coffee ground vomits) and Hb can be monitored instead

9

When is vit K indicated?

If bleeding when on warfarin OR in severe liver disease