Flashcards in Lipid Lowering Deck (9):
How do statins work?
Inhibiting HMG-CoA reductase
Inhibits hepatic cholesterol synthesis
Adverse effects of statins
Myopathy: includes myalgia, myositis, rhabdomyolysis and asymptomatic raised creatine kinase
What monitoring should be done with statins?
Check LFTs at baseline, 3 months and 12 months. Treatment should be discontinued if serum transaminase concentrations rise to and persist at 3 times the upper limit of the reference range
What are the risk factors for statin induced myopathy?
Risks factors for myopathy include advanced age, female sex, low body mass index and presence of multisystem disease such as diabetes mellitus.
Who should be given statins?
-All pts with established cardiovascular disease (stroke, TIA, ischaemic heart disease, peripheral arterial disease)
-QRISK2 >10% 10yr cardiovascular risk
-T1DM diagnosed more than 10 years ago OR are aged over 40 OR have established nephropathy
Dose and timing of statins
At night (esp simvastatin)
1º prevention: 20mg atorvastatin OD
2º prevention: 80mg atorvastatin OD
What fruit interacts with statins?
What is lipodystrophy syndrome?
Fat redistribution (buffalo hump)
Dyslipidaemia (raised LDL etc)