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Flashcards in Renal Deck (13)
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1
Q

Name a carbonic anhydrase inhibitor and MOA

A

Acetazolamide

Inhibits carbonic anhydrase in PCT

2
Q

Use of carbonic anhydrase inhibitor

A

Glaucoma

3
Q

SE of carbonic anhydrase inhibitor

A

Drowsiness, renal stones, metabolic acidosis

4
Q

Name 2 loop diuretics and MOA

A

Furosemide, bumetanide
InhibitS Na/K/2Cl symporter in thick ascending limb
Massive NaCl excretion, Ca and K excretion

5
Q

Use and SE of loop diuretics

A

Oedema – CCF, nephrotic syndrome,
hypercalcaemia
SE: hypokalaemic met alkalosis, ototoxic, hypovolaemia

6
Q

Name 2 thiazides and MOA and SE

A

Bendroflumethiazide
Indapamide
Inhibits NaCl co-transporter in DCT
Can cause gout

7
Q

SE methotrexate?

A

Can cause renal tubular acidosis
Also renally excreted so can build up in renal failure
-> neutropenia/pancytopenia

8
Q

How long does it take for a drug to reach steady state plasma concentration?

A

5 x half life

9
Q

Do you always reduce doses in renal impairment?

A

Not if loading dose is required for an immediate action

Give loading dose then reduce the maintenance doses

10
Q

When should creatinine clearance be used with caution?

A

Dependent on muscle mass and diet

CrCl caution: vegans, elderly, body builders, amputees, muscle wasting disorders

11
Q

Where do you find the eGFR and CrCl equations?

A

Prescribing in renal impairment

Halfway down the page

12
Q

When should eGFR not be used?

A

BMI above 40 or below 18

13
Q

How is CKD staged?

A

GFR vs ACR

Increased risk with both GRF reduction and ACR increase