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Flashcards in Renal Deck (13):
1

Name a carbonic anhydrase inhibitor and MOA

Acetazolamide
Inhibits carbonic anhydrase in PCT

2

Use of carbonic anhydrase inhibitor

Glaucoma

3

SE of carbonic anhydrase inhibitor

Drowsiness, renal stones, metabolic acidosis

4

Name 2 loop diuretics and MOA

Furosemide, bumetanide
InhibitS Na/K/2Cl symporter in thick ascending limb
Massive NaCl excretion, Ca and K excretion

5

Use and SE of loop diuretics

Oedema – CCF, nephrotic syndrome,
hypercalcaemia
SE: hypokalaemic met alkalosis, ototoxic, hypovolaemia

6

Name 2 thiazides and MOA and SE

Bendroflumethiazide
Indapamide
Inhibits NaCl co-transporter in DCT
Can cause gout

7

SE methotrexate?

Can cause renal tubular acidosis
Also renally excreted so can build up in renal failure
-> neutropenia/pancytopenia

8

How long does it take for a drug to reach steady state plasma concentration?

5 x half life

9

Do you always reduce doses in renal impairment?

Not if loading dose is required for an immediate action
Give loading dose then reduce the maintenance doses

10

When should creatinine clearance be used with caution?

Dependent on muscle mass and diet
CrCl caution: vegans, elderly, body builders, amputees, muscle wasting disorders

11

Where do you find the eGFR and CrCl equations?

Prescribing in renal impairment
Halfway down the page

12

When should eGFR not be used?

BMI above 40 or below 18

13

How is CKD staged?

GFR vs ACR
Increased risk with both GRF reduction and ACR increase