Complications of treatment in Oncology Flashcards Preview

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Flashcards in Complications of treatment in Oncology Deck (7)
1

What are the complications of chemotherapy?

Anaemia and Neutropenic Sepsis.
Chemotherapy can also cause bone marrow suppression.

2

What is defined as Neutropenic sepsis?

1. Temperature >38 on a single reading or >37.5 on 2 readings over 1 hour
2. Unexplained Low BP and Tachycardia
3. Neutrophil count of <1.0 x 10^9/L

3

What leads to tumour lysis syndrome?

When large amounts of tumour cells are lysed.

4

What are the 4 metabolic abnormalities that occur in Tumour Lysis Syndrome?

1. Hyperkalaemia
2. Hyperphosphataemia
3. Hyperuricaemia
4. Hypocalcaemia

5

How does hyperphosphataemia leads to AKI?

Hyperphosphataemia forms calcium phosphate crystals which deposits in kidneys, leading to AKI

6

What are the serious outcomes of Tumour Lysis Syndrome?

1. Uric acid nephropathy
2. Acute Kidney Failure
3. Seizures
4. Cardiac arrhythmias
5. Death

7

How will giving Allopurinol and Rasburicase help in Tumour Lysis Syndrome?

Allopurinol prevents the formation of uric acid.
Rasburicase (a synthetic urate oxidase enzyme) wash out excessive uric acid crystals.