Oncological Emergencies Flashcards Preview

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Flashcards in Oncological Emergencies Deck (3)
1

What are the causes of hypercalcemia in patients with cancer?

Hypercalcemia is often due to secretion of Parathyroid hormone-related protein (PTH-rP).
It can also be due to lytic bone metastases or the activation of osteoclasts, as seen in breast cancer and myeloma respectively.

2

Hypercalcaemia in malignancy is most common in which cancer types?

Breast cancer, lung cancer and multiple myeloma.

3

What is the immediate management of Hypercalcaemia?

Fluids, aiming for 3-6L of 0.9% NaCl over 24 hours. In severe cases, IV bisphosphonates can be given - reduce bone resorption.