Germ Cell Carcinoma Flashcards Preview

Haematology & Oncology > Germ Cell Carcinoma > Flashcards

Flashcards in Germ Cell Carcinoma Deck (9)
1

How are Germ cell carcinoma classified, based on histology??

Seminoma or Non-seminoma

2

Differentiate mature from immature teratoma

Mature teratoma are non-cancerous (they do not invade tissues), but they can grow rapidly.
Immature teratomas are cancerous.

3

A mature cystic teratoma in women is also known as a

Dermoid cyst

4

Compare seminoma and non-seminoma germ cell carcinoma in terms of mode of spread

Seminoma - Spreads via both lymphatic and blood vessels, but more commonly via the lymphatics. Pattern of spread is highly predictable - Para-aortic LN then pelvis and mediastinal.

In non-seminoma, lymphatic spread is similar to Seminoma, but is less predictable. Commonly spread to the lungs. Spread is rarely to the liver, brain, and bone (signifies poor prognosis if it occurs)

5

When is CT brain done for germ cell carcinoma?

If there is multiple lung metastases, and/or beta-HCG is >10,000

6

Tumour lysis syndrome is common in?

Common in patients who have large tumour volume, where the cancer is rapidly progressive.
Cancers with high cell turnover, and tumour proliferative states.

7

What is Tumour Lysis syndrome characterised by?

Characterised by a group of metabolic abnormalities:
1. Hyperkalaemia
2. Hyperphosphatemia
3. Hyperuricemia
4. Hypocalcaemia

8

What is an acute complication of cancer treatment?

Tumour lysis syndrome

9

What are the complications of Bleomycin?

Pulmonary fibrosis, fatal pneumonitis