MPN - Myeloproliferative Neoplasms Flashcards Preview

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Flashcards in MPN - Myeloproliferative Neoplasms Deck (9)
1

What are the 4 major conditions in MPN?

1. CML - Chronic Myeloid Leukaemia
2. Polycythaemia Vera
3. Essential thrombocythaemia
4. Primary Myelofibrosis

2

What is the effect of excessive alcohol consumption on platelet count, and haemoglobin (Hb)?

Excessive alcohol consumption can decrease platelet count and increase Hb.

3

What are the causes of secondary/reactive thrombocythaemia?

1. Infection: most common of which are pneumonia, meningitis, UTI, etc.
2. Inflammation: Inflammatory conditions incl IBD or Rheumatoid arthritis
3. Trauma: burns
4. Post-splenectomy or hyposplenism

4

What investigative factors are likely to be raised in secondary thrombocythaemia?

ESR, CRP, Fibrinogen levels, Factor VIII pro-coagulant activity and Von Willebrand antigen level.

5

What are the hallmark features of Essential thrombocythaemia?

1. Sustained rise in thrombocytes/platelets >600 x 10^9/L.
2. Megakaryocyte hyperplasia
3. Splenomegaly
4. an increased tendency to both thrombosis and bleeding

6

Which condition is positive for the Philadelphia chromosome?

Chronic Myeloid Leukaemia

7

What is the Philadelphia chromosome?

A translocation mutation between chromosomes 9 and 22, resulting in BCR-ABL1 gene.

8

Antiphospholipid antibodies increase/decrease risk of thrombosis?

Antiphospholipid antibodies increases risk of thrombosis.

9

Is the EPO level in PV high or low?
How about in secondary polycythaemia?

EPO level in PV is low.
EPO is high in secodnary polycythaemia.