Ovarian cancer Flashcards Preview

Haematology & Oncology > Ovarian cancer > Flashcards

Flashcards in Ovarian cancer Deck (9)
1

Which cancer marker will be raised in Ovarian cancer?

CA-125.
However, this is not specific to ovarian cancer. it is also raised in inflammation, infection and infarction.

2

When to test for Ovarian cancer?

Carry out tests in those 50 years old or older, with the following symptoms occurring at 12 or more times per month:
- persistent abdominal distension (often referred to as "bloating")
- early satiety and/or loss of appetite
- pelvic or abdominal pain
- increased urinary urgency and/or frequency

Also carry out tests when a women aged 50 or more experience symptoms suggesting Irritable Bowel Syndrome (IBS) within the last 12 months, because IBS seldom presents for the first time in women of this age.

3

What is done to test for Ovarian cancer?

CA-125 levels is tested. If >35IU/ml or greater, arrange an ultrasound scan of abdomen and pelvis

4

If USS, CA125 and clinical status suggests ovarian cancer, what is the next step?

CT scan of pelvis and abdomen. Include the thorax if clinically indicated

5

What is done for definitive diagnosis of ovarian cancer?

Tissue biopsy:
use percutaneous image-guided biopsy if feasible.
If not, consider laparoscopic biopsy.

6

What signs and symptoms are seen in more advanced ovarian cancers? Complications

Pleural effusions
Ascites
Malignant bowel obstruction
Thromboembolic phenomenon
Kidney problems - hydronephrosis secondary to ureteric obstruction
Inflammatory myopathies - dermatomyositis

7

How is the staging and determination of extent of spread of ovarian cancer determined?

It is determined with surgery.

8

CA-125, transvaginal USS findings and age can be useful in what aspects?

CA-125, transvaginal ultrasound findings and age can be useful in differentiating benign ovarian cysts and ovarian malignancy.

9

Which type of ovarian cancer is most common?

Ovarian cancer of epithelial origin - especially serous > mucinous - forms 90% of cases.