Parksinsons Flashcards Preview

Neurology > Parksinsons > Flashcards

Flashcards in Parksinsons Deck (68)
Loading flashcards...
1

Age of presentation of Parkinson’s ?

45-60

2

Parkinsonism triad?

Bradykinesia, tremor, rigidity. Usually bilateral but can start unilateral

3

What happens to tremor in Parkinson’s ?

Disappears with activity

4

What is rigidity?

Increased resistance to passive movement

5

What is rigidity like throughout the range of movement ?

Equal throughout

6

Gait in Parkinson’s ?

Show, shuffling gait

7

Arms and posture during walking ?

Stopped posture and reduced arm swing

8

What is speech like ?

may be slow and monotonous. In late stage disease may be slurred, or even lost

9

Power and sensory loss?

Power remains normal and there is no sensory loss

10

What other psychiatric conditions associated with Parkinson’s ?

Dementia and depression

11

Why do you get hallucinations.

A combination of the disease and the drugs used. Often they are not unpleasant

12

What are kayser fleisher rings seen in?

Wilson’s disease (copper)

13

Which drugs can cause Parkinsonism?

Drugs (usually dopamine antagonsists)–e.g. prochlorperazine, metoclopramide (antiemetics) phenozanthines, butyrophenones (neuroleptics)

14

pathological hallmark of parkinsons disease

prominent dopaminergic neurone loss in the substantial nigra with alphasyneuclein containing lewey bodies and lewey neurites

15

which part of the brain is the substantial nigra found?

basal ganglia

16

what are upper motor neurone features?

pyramidal weakness and spasticity

17

triad of parkinsonianism?

bradykinesia, resting tremor and rigidity

18

Fragments of movements flow irregularly from one body segment to another causing a dance-like appearance?

chorea

19

what does PD present with?

PD presents with tremor, muscular rigidity, akinesia, rest tremor, and gait and postural impairment

20

which subtype has the slower rate of progression ?

tremor dominant

21

non motor features of PD?

olfactory dysfunction, cognitive impairment, psychiatric symptoms, sleep disorders, autonomic dysfuncLon, pain, and faLgue.

22

when does diagnosis occur in PD?

with the onset of motor symptoms

23

what is progression of PD characterised by?

progression of motor symptoms

24

Neuronal loss in PD occurs in many other regions including?

ocus ceruleus, nucleus basalis Meynert, pedunculoponLne and raphe nuclei, dorsal motor nucleus of vagus, amygdala, hyopthalamus

25

how are lewey bodies formed?

Misfolded α-synuclein,which is insoluble and aggreagated, forms intracellular inclusions (Lewy bodies)

26

Prolonged muscle spasms and abnormal postures

dystonia

27

Fragments of movements flow irregularly from one body segment to another causing a dance-like appearance

chorea

28

a parasomnia characterized by abnormal or disrupLve behaviours (such as talking, laughing, shouLng, gesturing, grabbing, punching, kicking,, sirng up in bed)

Rapid eye movement sleep behaviour

29

treatment of rapid eye movement sleep disorder?

clonazepam or malatonin

30

what is the frequency of the rest tremor in parkinsons?

4-6Hz