Antiepileptic drugs Flashcards Preview

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Flashcards in Antiepileptic drugs Deck (13):
1

What triggers an action potential?

Opening of Na+ channels; depolarising the membrane

2

What channel opens after the initial depolarisation of the membrane?

Opening of calcium channels; triggering the release of glutamate in the synaptic cleft

3

What receptors will glutamate bind to on the post-synaptic cleft?

AMPA; permit entry of sodium
NMDA; open and permit entry of calcium ions

4

What receptor will GABA bind to on excitatory neurones?

GABA-A

5

What ion channel opens on the excitatory neuron when GABA binds?

Chloride (negative)

6

Which antiepileptics antagonise the sodium channels of the presynaptic neurone?

Carbamazepine
Lamotrigine
Phenytoin
Topiramate
Sodium valproate

7

Which antiepileptics antagonise the presynaptic calcium channels?

Lamotrigine
Topiramate

8

Which antiepileptics antagonise the postsynaptic T type calcium channels?

Sodium valproate

9

Mechanism of action of gabapentin and pregabalin?

Bind to alpha 2 delta 1 to block calcium entry into the presynaptic neurone

10

Mode of action of levetiracetam?

Binds to SV2A which is a membrane protein on the vesicles that contain glutamate; and therefore prevents glutamate release into the synaptic cleft

11

Which antiepileptic results in hyponatremia?

Carbamazepine

12

Which antiepileptics can result in blurred vision?

Lamotrigine
Phenytoin (can also cause gingival hyperplasia and hirsutism)

13

Side effects of sodium valproate?

Weight gain
Liver toxicity
TERATOGENIC