Flashcards in Parkinson's drugs Deck (6)
How is dopamine synthesised?
Tyrosine converted to L-dopa
L-dopa decarboxylated to dopamine
Loaded into presynaptic vesicles
What enzyme metabolises dopamine?
MAO (type B)
What must levodopa be co-administered with?
Carbidopa; inhibits dopa decarboxylase and reduced peripheral conversion
What is the mode of action of entacapone?
Inhibits peripheral COMT (prevents peripheral conversion)
Examples of direct dopamine agonists?