Parkinson's drugs Flashcards Preview

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Flashcards in Parkinson's drugs Deck (6):
1

How is dopamine synthesised?

Tyrosine converted to L-dopa
L-dopa decarboxylated to dopamine
Loaded into presynaptic vesicles

2

What enzyme metabolises dopamine?

MAO (type B)
COMT

3

What must levodopa be co-administered with?

Carbidopa; inhibits dopa decarboxylase and reduced peripheral conversion

4

What is the mode of action of entacapone?

Inhibits peripheral COMT (prevents peripheral conversion)

5

Examples of direct dopamine agonists?

Bromocriptine
Ropinirole

6

What nT is increased in parkinson's disease?

Reduced dopamine results in increased ACh
Overstimulation of muscarinic receptors results in tremors and rigidity