Flashcards in Neurotransmission Deck (13)
Amino acid neurotransmitters
Which neurotransmitter receptors are ligand gated ion channels?
Inotropic; membrane receptors directly coupled to an ion channel. Transmission is fast
Which neurotransmitters are GPCR?
Metabotropic; modulates the activity of ion channels indirectly and therefore slower
What are the main excitatory neurotransmitters that result in the production of an EPSP?
What are the main inhibitory neurotransmitters that result in an IPSP?
Act via chloride or potassium channels
What is temporal summation?
Occurs when EPSPs arrive rapidly one after the other at the same target cell, without time to decay and therefore bringing the membrane potential to threshold
What is spatial summation?
ESPS from different sites on the neuron combine at the same time
Mechanism of action of AMPA receptrs
Mechanism of action of NMDA receptors
Permeable to Ca2+
Removal of Mg 2+ via depolarisation to allow Ca2+ to enter