Neurotransmission Flashcards Preview

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Flashcards in Neurotransmission Deck (13):
1

Amino acid neurotransmitters

Glutamate
GABA
Glycine

2

Monoamine neurotransmitters

ACh
Adrenaline
NA
Dopamine
Serotonin
Histamine

3

Purine neurotransmitters

Adenosine
ATP

4

Peptide neurotransmitters

Substance P
Endorphin
Dynorphins
Somatostatin
CCK

5

Which neurotransmitter receptors are ligand gated ion channels?

Inotropic; membrane receptors directly coupled to an ion channel. Transmission is fast

6

Which neurotransmitters are GPCR?

Metabotropic; modulates the activity of ion channels indirectly and therefore slower

7

What are the main excitatory neurotransmitters that result in the production of an EPSP?

Glutamate
ACh

8

What are the main inhibitory neurotransmitters that result in an IPSP?

GABA
Glycine
Act via chloride or potassium channels

9

What is temporal summation?

Occurs when EPSPs arrive rapidly one after the other at the same target cell, without time to decay and therefore bringing the membrane potential to threshold

10

What is spatial summation?

ESPS from different sites on the neuron combine at the same time

11

Mechanism of action of AMPA receptrs

Glutamate binds
Conformational shift
Na+ influx

12

Mechanism of action of NMDA receptors

Permeable to Ca2+
Removal of Mg 2+ via depolarisation to allow Ca2+ to enter

13

Where are GABA neurotransmitters most abundant?

Cerebellum
Basal ganglia
Interneurons to regulate muscle tone