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Flashcards in Bleeding disorders Deck (44)
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1

Bleeding that is:
-superficial
-petechiae
-spontaneous

Platelet bleeding

2

Bleeding that is:
-deep joints
-Big bleeds
-Trauma

Factor bleeding

3

Most common hereditary bleeding disorder

Autosomal dominant

Variable severity

Von Willebrand Disease

**vW factor decreased or abnormal

4

vW factor made where?

megakaryocytes and subendothelial cells

5

vWF carries what factor?

VIII

6

Three types of vW disease:

Type 1 (70%) : decreased vWF

Type 2 (25%) : abnormal vWF

Type 3 (5%) : no vWF

7

Sx of vW disease?

mucosal bleeding

deep joint bleeding (severe cases)

8

What test will be NORMAL in a pt with vW disease?

INR

9

Platelet membrane protein that binds vWF?

GP Ib

10

Tx fro vW disease?

DDAVP (for type I)

Cryoprecipitate (contains vWF and VIII)

Factor VIII

11

X-linked recessive bleeding disorders:

hemophilia A and B

12

most common FACTOR deficiency

factor VIII decreased

hemophilia A

13

common sx of hemophilia A:

deep joint bleeding

prolonged bleeding after dental work

14

NORMAL lab results in hemophilia A and B?

INR

TT

Platelet count

bleeding time

15

What does PTT look like in hemophilia?

prolonged (low factor VIII or IX)

**corrects with mixing study

16

Tx of hemophilia A:

DDAVP

Factor VIII

17

What is the difference between hemophilia A and B

A = VIII problem

B = IX problem, MUCH LESS COMMON

18

Rare; bleeding only after trauma:

XI deficiency

19

severe neonatal bleeding

XIII

20

Crosslinks fibrin --> clot

XIIIa

21

Abnormal GP Ib

Big platelets

Severe Bleeding

Bernard-Soulier Syndrome

22

No IIb-IIIa

No aggregation

Severe bleeding

Glanzmann Thrombasthenia

23

No alpha granules in platelets

Big, empty platelets

Mild bleeding

Gray Platelet Syndrome

24

Platelet prob related to Chediak-Higashi?

delta Granule deficiency

25

Lots of causes

coag triggered causing thrombosis

platelets and factors get used up, causing bleeding

MAHA

DIC

**Disseminated Intravascular Coagulation

26

DIC triggers that "dump" coag factors causing DIC:

OB complications

Adenocarcinoma

AML (promyelocytic)

27

DIC triggers that "rip" endothelial cells apart causing DIC:

Bacterial sepsis

Trauma

Burns

Vasculitis

28

Top 4 causes of DIC*****:

Malignancy

OB complications

Sepsis

Trauma

29

INR, PTT, TT in DIC?

prolonged

30

FDP's in DIC?

increased