Block 2 high yield Flashcards Preview

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Flashcards in Block 2 high yield Deck (97)
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1

alpha/beta T cells

bind MHC I and II

2

gamma/delta T cells

bind dirctly w/o MHC

protect mucosal surfaces

3

T cell

IFN-y

angry mac's

Th1

4

like Th1 but more powerful

Th17

5

Th's promote healing

Th2

6

Th's

help B-cells activate and class switch

Thf

7

Th's

IL-10

Tregs

8

APC --- T cell binding

first signal molecules

APC MHC ---- TCR (CD8 or CD4)

9

APC --- T cell co-stim

APC B7 (CD 80/86) ---- T cell CD28

10

APC ---- T cell

adhesion

APC ICAM 1/3 ----- T cell LFA-1

11

2 general T cell activators

IL-2

IL-15

12

Th1 activators

IL-12

INF-y

13

Th2 activator

IL-4

14

down regulates Th1's

IL-10

15

down regulates Th1's and 2's

TGF-B

16

FAS

target cell receptor inducing caspase --> apoptosis

17

FAS ligand

T-cell molecule --> binds FAS --> apoptosis of target cell

18

most abundant Ig

crosses placenta

IgG

19

first, biggest Ig

IgM

20

B cell membrane Ig....that's all

IgD

21

Ig in secretions

IgA

22

Ig attaches to Mast cells

IgE

23

IgE mediated hypersensitivity

Type 1

24

Automimmune Ig mediated hypersensitivity

Type 2

25

Immune complex mediates hypersensitivity

Type 3

26

T-cell mediated hypersensitivity

Type 4

27

No B-cells

X-linked agammaglobulinemia

28

failure of Ig class switching

CD40 ligand def

or

Activation induced Cytidine deaminase def

29

failure to produce Ig's against certain antigens

common variable immunodeficiency

30

VDJ recombination failure... no BCR or TCR

Omenn Syndrome