Flashcards in Block 2 high yield Deck (97)
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1
alpha/beta T cells
bind MHC I and II
2
gamma/delta T cells
bind dirctly w/o MHC
protect mucosal surfaces
3
T cell
IFN-y
angry mac's
Th1
4
like Th1 but more powerful
Th17
5
Th's promote healing
Th2
6
Th's
help B-cells activate and class switch
Thf
7
Th's
IL-10
Tregs
8
APC --- T cell binding
first signal molecules
APC MHC ---- TCR (CD8 or CD4)
9
APC --- T cell co-stim
APC B7 (CD 80/86) ---- T cell CD28
10
APC ---- T cell
adhesion
APC ICAM 1/3 ----- T cell LFA-1
11
2 general T cell activators
IL-2
IL-15
12
Th1 activators
IL-12
INF-y
13
Th2 activator
IL-4
14
down regulates Th1's
IL-10
15
down regulates Th1's and 2's
TGF-B
16
FAS
target cell receptor inducing caspase --> apoptosis
17
FAS ligand
T-cell molecule --> binds FAS --> apoptosis of target cell
18
most abundant Ig
crosses placenta
IgG
19
first, biggest Ig
IgM
20
B cell membrane Ig....that's all
IgD
21
Ig in secretions
IgA
22
Ig attaches to Mast cells
IgE
23
IgE mediated hypersensitivity
Type 1
24
Automimmune Ig mediated hypersensitivity
Type 2
25
Immune complex mediates hypersensitivity
Type 3
26
T-cell mediated hypersensitivity
Type 4
27
No B-cells
X-linked agammaglobulinemia
28
failure of Ig class switching
CD40 ligand def
or
Activation induced Cytidine deaminase def
29
failure to produce Ig's against certain antigens
common variable immunodeficiency
30
