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Flashcards in Block one high yield Deck (67):
1

pluripotent stem cell + IL-3

lymphoid progenitor

2

pluripotent stem cell + IL-3 + GM-CSF

myeloid progenitor

3

plasma vs serum?

plasma has fibrinogen

serum does not

4

3 RBC cytoskeleton proteins:

spectrin

ankyrin

actin

5

no ankyrin inRBC --> ?

hereditary spherocytosis

6

myeloperoxidase

neutrophil

Azurophilic granule

7

lysozyme

lactoferrin

neutrophilic specific granules

8

gelatinase

tertiary granules

9

major basic protein

cationic protein

Eosinophil specific granules

10

Bid/Bax

pro-apoptotic

11

Bcl-2/Bid

antiapoptotic

12

genome: dsRNA segmented

tropism: pro-erythroblasts

travel to mountain west

Colorado tick fever virus

13

genome: dsDNA

tropism: systemic; latent in CD34+ cells (monocyte-->macrophage)

heterophile Ab negative

Owl’s eyes cells

Congenital --> deafness

Cytomegalovirus

14

genome: dsDNA

tropism: CD4+ T cells, others: PBMNCs, epithelial cells

exanthem subitum (aka roseola): rash that develops after a fever resolves

heterophile Ab negative mononuceosis

HHV6, HHV7

15

genome: dsDNA

tropism:
Acute: epithelial cells of oropharynx (supports lytic life cycle)
Latent: B cells

infectious mononucleosis: Heterophile Ab positive mono

Burkitt lymphoma: t(8:14)
Hodgkin & non-Hodgkin lymphoma
nasopharyngeal lymphoma
X-linked lymphoproliferative disease: inherited mutation in SAP adapter

Epstein Bar virus

16

genome: dsDNA

tropism: epithelial cells; B cells

in immunocompromised patients only:

primary effusion lymphoma

multifocal Castlemans disease

Karposis sarcoma virus

17

genome: ssRNA + or -

tropism: erythroid progenitor cells

NO envelope

erythema infectiosum: fiery red rash on cheek.

Transient aplastic crisis: in patients with underlying anemia

parvovirus B19

18

genome: ssRNA+

tropism: T-cells

Acute T cell lymphoma / leukemia (ATL): Viral transcription factor Tax drives proliferation; blocks apoptosis.

HAM/TSP: Inflammation on the spine

Human T-cell Lymphoma virus 1 and 2

1 > CD4's

2> CD8's

19

genome: ssRNA -

tropism: macrophages

capsid: HELICAL

Hemorrhagic fever

Ebola

20

T-cell zone of lymph node

paracortex (deep)

21

Lymph flow through node...

Afferent lymphatic vessels

Subcapsular sinus

Trabecular sinus

Paracortical sinus

Medullary sinus

Efferent lymphatic vessel

22

Prevents antigen in blood from entering thymic cortex

Blood-thymus barrier

23

Largest lymphatic organ

spleen

24

TLR ?

dsRNA

TLR 3

25

TLR ?

LPS

TLR 4

26

TLR ?

Triacyl Lipoprotein

TLR 1 and 2

27

TLR ?

Diacyl Lipoprotein

TLR 6 and 2

28

TLR ?

flagellin

TLR 5

29

TLR ?

ssRNA

TLR 7/8

30

TLR ?

CpG-DNA

TLR 9

31

E-selectin binds:

CD-15

32

Leukocyte adhesion molecules:

CR3/LFA-1 ----- ICAM-1

33

GM-CSF + G-CSF + IL-3 = ?

neutrophil

34

GM-CSF + IL-3 + IL-5 = ?

eosinophil

35

GM-CSF + IL-3 + IL-4 = ?

basophil

36

GM-CSF + M-CSF + IL-3 = ?

monocyte

37

monocyte + M-CSF + GM-CSF = ?

macrophage

38

monocyte + GM-CSF + IL-4 = ?

dendrite

39

1. IL-3

2. SCF + IL-2

NK cell

40

No GM-CSF

Congenital neutropenia

(no myeloid cells)

inc. bacterial infx

41

microcytic, hypochromic RBCs

anisocytosis (unequal size)

poikilocytosis (funny shape)

GI bleeding

Iron deficiency anemia

**abnormal iron studies

42

Iron transporter in blood

transferrin

43

Iron state that binds O2

Fe2+ ferrous

44

Fe3+

ferric

"methemoglobin"

45

craving dirt, ice, windex

Pica

iron deficiency anemia

46

TIBC in Fe deficiency?

increased

47

ferritin in Fe deficiency

decreased

48

defective DNA synth

B12/folate def

**hypersegmented neuts**

Megaloblastic anemia

49

lack of intrinsic factor on gut epithilial cells

pernicious anemia

**can't absorb B12

50

normochromic, normocytic

spherocytes

targets, sickles, fragmented RBCs

Hemolytic anemia

51

anemia, jaundice, splenomegaly

**parvovirus maybe

Hereditary spherocytosis

52

IgG

Spleen

Spherocytes

Warm Autoimmune Hemolytic Anemia

53

IgM, complement

some intravascular hemolysis

mostly spleen

agglutination

Cold autoimmune hemolytic anemia

*IgM falls off in warm body parts

54

Isoniazid tx of TB associated with?

B6 deficiency

55

Increased indirect (unconjugated) bilirubin associated with?

hemolysis

56

Increased direct (conjugated) bilirubin associated with?

biliary obstruction

57

Sporadic Porphyria cutanea tarda associated with?

Hep C

58

Increased hepcidin?

Anemia of Chronic Disease

59

Vegan's don't absorb iron as well as meat eaters because?

Veggies have Fe3+ (ferric)

60

Long term Iron storage

hemosiderin

61

Lets Iron out of cells

Ferroprotin

62

Blocks ferroportin, keeping Fe in cells:

hepcidin

63

Increased Hepcidin probably means:

Anemia of chronic disease

64

Decreased hepcidin means:

iron over load----to much iron gets through ferroportin into blood

65

HFE gene mutation

hereditary hemachromatosis

decreased hepcidin expression

inc serum iron

66

Triad sx for hereditary hemachromatosis

1. DM

2. Hepatomegaly

3. Hyperpigmentation

67

Tx for hemachromatosis

phlebotomy