Flashcards in Block 5 highish yield Deck (35):
1
reduced IL-2 and expression of IL-2R (CD25) is a result of:
reduced antigen exposure
2
no Tregs
IPEX
3
problem caused by IPEX
out of control T-cells
4
Treg autocrine cytokine?
IL-35
5
genetic cause of IPEX
mutated FOXP3
6
overexpression of thyroid hormones
Grave's disease
7
high MHC II induces
Th1
Th17
8
low MHC II induces
Th2
9
CXCR3
CCR5
Th1
10
CCR3
CCR4
CCR8
Th2
11
CCR6
Th17
12
Mutation in CCR5
HIV resistance
13
anti-nuclear antibodies
SLE
14
dsDNA and Smith (Sm) antigen antibodies
SLE
15
SLE hypersensitivity
Type III
immune complex mediated
16
anti-phospholipid antibodies
SLE
17
acute necrotizing vasculitits
SLE
18
SS-A
HLA-DR3
Subacute cutaneous LE
19
autoantibodies for CCPs
RA
20
dry eyes
dry mouth
SS-A
SS-B
Sjogren Syndrome
21
perivascular fibrosis
systemic sclerosis
22
Scl-70 antibodies
systemic sclerosis
23
anti-centromere antibodies
CREST syndrome
24
Raynaud's
systemic sclerosis
25
anti-U1-RNP
mixed connective tissue disease
26
Btk
XLA
27
B-cells present
don't differentiate into plasma cells
CVID
28
failure of thymus development
DiGeorge
29
22q11
DiGeorge
30
X-linked recessive CD40L mutation
Hyper IgM syndrome
31
P. jiroveci
Hyper IgM syndrome
32
defect in humoral and cell mediated immunity
usually X-linked gamma chain cytokine receptor mutation
SCID
33
ADA
SCID
34
Thrombocytopenia
Eczema
variable loss of cell mediated immunity
Wiskott-Aldrich
35