Block 3 high yield Flashcards Preview

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Flashcards in Block 3 high yield Deck (103)
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1

Fibrinoid necrosis

Type ? hypersensitivity

Type 3

2

granuloma with central necrosis

caseating

ie. TB

3

HER-2/NEU overexpression

breast cancer

4

KRAS mutation

colorectal cancer

5

N-MYC gene amplification

neuroblastoma

6

t(8;14)

Burkitt Lymphoma

7

t(9;22)

CML

8

BCR-ABL

CML

9

"Two hit" hypothesis

lose BOTH tumor suppressor genes

10

Rb mutation

13q14

retinoblastoma

11

APC tumor supressor gene

colorectal carcinoma

12

BCRA1/BCRA2

breast
ovary
prostate

cancers

13

molecular "policeman"

p53

14

high glucose use by cancer cells

Warburg Effect

15

t(14;18)

overexpressed BCL-2

B-cell lymphoma

16

immortality of cancer cells -- evasion of mitotic crisis

maintenance of telomeres

17

Th1's polarized by:

IL-12

IL-18

INF-y

18

Th1's secrete:

INF-y

TNF

19

Th17's polarized by:

TGF-B

IL-1

IL-6

IL-23

20

Th17's secrete:

IL-17

IL-22

21

Th2's polarized by:

IL-4

22

Th2's secrete:

IL-4

IL-5

IL-13

23

Tfh's polarized by:

IL-6

IL-21

24

Thf's secrete:

IL-4

IL-21

25

Treg's polarized by:

IL-2

TGF-B

26

Treg's secrete:

IL-10

TGF-B

27

No Treg's?

IPEX

out of control T-cells

28

T-bet

Th1

29

GATA3

Th2

30

RORyt

Th17