Block 4 highish yield Flashcards Preview

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Flashcards in Block 4 highish yield Deck (98)
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1

Don't let the sun set on...

AML M3

2

Most common leukemia in adults

CLL

3

CLL

mutated Ig Vh genes

better prog

4

Elevated B2 microglobulin

soluble CD23

CD38+

ZAP-70+

poor prog in CLL

5

13q-

best prog in CLL

6

17p-

worst prog in CLL

acts like mantle cell

7

CD38+

unmutated Ig genes = poorer prog CLL

8

NIGHT SWEATS

CLL

9

CTLA-4

binds B7

prevents runaway T-cell activity

10

Location of MHC I synthesis

RER

11

TAP 1 and 2

gets antigen into RER for upload on MHC I

12

ERAAP

inside RER

helps load antigen onto MHC I

13

Location of antigen loading onto MHC II

late endosome

14

"place holder" on MHC II

invariant chain

15

part of digested invariant chain left in MHC II

CLIP

16

replaces CLIP with antigen on MHC II

HLA-DM

17

inhibits HLA-DM

HLA-DO

18

location of invariant chain loading onto MHC II

RER

19

licenses DCs to cross present

CD40--CD40L

20

CD40 on what cell

DC

21

CD40L on what cells

Th's

22

MHC II expression stimulated by

INF-y

23

TdT alone

early pro-B cell

24

TdT and CD45R

intermediate pro-B-cell

25

CD45R

downregulated TdT

Late pro-B cell

26

receptor for B cell growth and differentiation

CD45R

27

pro-B cell, chain recombination?

H-chain

DJ--VDJ

28

pre-B cell, chain recombination?

L-chain

V-J

**small pre-B cell

29

cytokine for B cell division and differentiation

IL-7

30

Btk

Bruton's tyrosine kinase

XLA

no/few B-cells