Flashcards in Block 4 highish yield Deck (98)
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1
Don't let the sun set on...
AML M3
2
Most common leukemia in adults
CLL
3
CLL
mutated Ig Vh genes
better prog
4
Elevated B2 microglobulin
soluble CD23
CD38+
ZAP-70+
poor prog in CLL
5
13q-
best prog in CLL
6
17p-
worst prog in CLL
acts like mantle cell
7
CD38+
unmutated Ig genes = poorer prog CLL
8
NIGHT SWEATS
CLL
9
CTLA-4
binds B7
prevents runaway T-cell activity
10
Location of MHC I synthesis
RER
11
TAP 1 and 2
gets antigen into RER for upload on MHC I
12
ERAAP
inside RER
helps load antigen onto MHC I
13
Location of antigen loading onto MHC II
late endosome
14
"place holder" on MHC II
invariant chain
15
part of digested invariant chain left in MHC II
CLIP
16
replaces CLIP with antigen on MHC II
HLA-DM
17
inhibits HLA-DM
HLA-DO
18
location of invariant chain loading onto MHC II
RER
19
licenses DCs to cross present
CD40--CD40L
20
CD40 on what cell
DC
21
CD40L on what cells
Th's
22
MHC II expression stimulated by
INF-y
23
TdT alone
early pro-B cell
24
TdT and CD45R
intermediate pro-B-cell
25
CD45R
downregulated TdT
Late pro-B cell
26
receptor for B cell growth and differentiation
CD45R
27
pro-B cell, chain recombination?
H-chain
DJ--VDJ
28
pre-B cell, chain recombination?
L-chain
V-J
**small pre-B cell
29
cytokine for B cell division and differentiation
IL-7
30
