Block 4 highish yield Flashcards Preview

IHO week 6 and Final > Block 4 highish yield > Flashcards

Flashcards in Block 4 highish yield Deck (98)
1

Don't let the sun set on...

AML M3

2

Most common leukemia in adults

CLL

3

CLL

mutated Ig Vh genes

better prog

4

Elevated B2 microglobulin

soluble CD23

CD38+

ZAP-70+

poor prog in CLL

5

13q-

best prog in CLL

6

17p-

worst prog in CLL

acts like mantle cell

7

CD38+

unmutated Ig genes = poorer prog CLL

8

NIGHT SWEATS

CLL

9

CTLA-4

binds B7

prevents runaway T-cell activity

10

Location of MHC I synthesis

RER

11

TAP 1 and 2

gets antigen into RER for upload on MHC I

12

ERAAP

inside RER

helps load antigen onto MHC I

13

Location of antigen loading onto MHC II

late endosome

14

"place holder" on MHC II

invariant chain

15

part of digested invariant chain left in MHC II

CLIP

16

replaces CLIP with antigen on MHC II

HLA-DM

17

inhibits HLA-DM

HLA-DO

18

location of invariant chain loading onto MHC II

RER

19

licenses DCs to cross present

CD40--CD40L

20

CD40 on what cell

DC

21

CD40L on what cells

Th's

22

MHC II expression stimulated by

INF-y

23

TdT alone

early pro-B cell

24

TdT and CD45R

intermediate pro-B-cell

25

CD45R

downregulated TdT

Late pro-B cell

26

receptor for B cell growth and differentiation

CD45R

27

pro-B cell, chain recombination?

H-chain

DJ--VDJ

28

pre-B cell, chain recombination?

L-chain

V-J

**small pre-B cell

29

cytokine for B cell division and differentiation

IL-7

30

Btk

Bruton's tyrosine kinase

XLA

no/few B-cells

31

reduced serum IgG, memory B cells

CVID

32

Prototypical TI-1 antigen

(T cell independent)

LPS

33

TI-2 antigen

large polysaccharides

34

TLR4 TI 1 B cell activation

polyclonal

35

BCR TI 1 B cell activation

clonal

36

B1 B cells bind type 2 TI antigens via...

cross-linking of BCR

clonal

37

"handcuffs" T-cell to APC ---> too many Th1's!

superantigen

38

CTL-Ps activated by..

licensed APCs

39

APCs licensed by...

Th1

Th17

PAMP+TLR

40

CTL-P activation molecules (4)

TCR--MHC I

CD28--CD80/86

41

no IL-2 or CD25(IL-2R)

high L-selectin and CCR7

low CD44 and LFA-1

naive CTL-P

42

CTL-P homing and retention in the lymph node

CCR7

43

CTL Effector homing and retention at sites of inflammation

CD44 and LFA-1

44

LFA-1

on CTL

binds ICAMs on target cell

45

most effective NKs at killing target cells

CD56 low

46

NK activity stimulated by:

INF-a
INF-B
INF-y
TNF-a
IL-15

47

CD16

NKs

recognizes IgG

48

only inhibitory NK lectin-like receptor

CD94 aka NKG2A

**trumps everything

49

only activating NK immunoglobulin-like receptor

KIR2DS1

50

activation of NK cell

must bump into inhibitory signal at least once

51

CMD

neutrophils

CML

52

CMD

RBCs

Polycythemia vera

53

CMD

platelets

Essential thrombocythemia

54

CMD

everything

Myelofibrosis

55

Basophilia

CML

56

Philadelphia

CML

57

Jak-2 mutation

Polycythemia vera

58

Plethora (flushing)

Polycythemia vera

59

high platelet count in YOUNG WOMEN

Essential thrombocythemia

60

Massive extramedullary hematopoiesis

Teardrop red cells

Chronic myelofibrosis

61

t(9;22)

CML

62

BCR-ABL

CML

63

auto inhibitor of ABL1

Myristate

64

added from BCR

creates new binding site for intracellular signalling

Tyrosine-177

65

specific ABL kinase inhibitor

Imantinib

66

monoclonal plasma cell proliferation

osteolytic lesions

Multiple myeloma

67

Bence-Jones proteins

Multiple myeloma

68

stacking of RBCs like coins

rouleaux

multiple myeloma

69

amyloid in marrow from light chain aggregates

multiple myeloma

70

Plasma cell tumor

IgM

Waldenstrom macroglobulinemia

71

classic triad for MM:

anemia

bone pain

renal failure

72

CD5+ B cells

CLL

73

bcl-2 rearrangment

CLL

74

Splenomegaly without lymphadenopathy

TRAP+

Hairy Cell Leukemia

75

CD25+

CD11c+

CD5-

Hairy Cell Leukemia

76

T-cell CLL

neutropenia

Large Granulated Lymphocytic Leukemia

77

Tingible body macrophages

Follicular hyperplasia

78

Partial effacement

T-cell response to immune stimulus

Interfollicular hyperplasia

79

Lymphoma

same as CLL

Small Lymphocytic Lymphoma

80

t(11;14)

Mantle Cell Lymphoma

81

t(14;18)

Follicular Lymphoma

82

"butt cells"

Follicular Lymphoma

83

Cerebriform lymphocytes

Skin lesions

T-cell

Mycosis Fungoides

84

Large mitotically active B cells

Diffuse Large Cell Lymphoma

85

Lymphoma same as ALL

Lymphoblastic

86

Teenage male with mediastinal mass

Lymphoblastic lymphoma

87

Starry-sky

Burkitt Lymphoma

88

t(8;14)

Burkitt Lymphoma

89

Reed-Sternberg cells

Hodgkin Lymphoma

90

Popcorn cells

Nodular L-P Hodgkin Lymphoma

91

Lacunar cells

Nodular Sclerosis Hodgkin Lymphoma

92

Collagen or reticulin background

Lymphocyte depletion Hodgkin Lymphoma

93

therapy induced lung disease

bleomycin

94

anti-CD20 "difference maker" tx

rituximab

95

prototypical agressive NHL

Diffuse Large B Cell

96

cyclin D+

Mantle Cell Lymphoma

97

H. pylori

MALT Lymphoma

98

prototypical T-cell lymphoma

Mycosis Fungoides