Flashcards in Block 4 highish yield Deck (98):
1
Don't let the sun set on...
AML M3
2
Most common leukemia in adults
CLL
3
CLL
mutated Ig Vh genes
better prog
4
Elevated B2 microglobulin
soluble CD23
CD38+
ZAP-70+
poor prog in CLL
5
13q-
best prog in CLL
6
17p-
worst prog in CLL
acts like mantle cell
7
CD38+
unmutated Ig genes = poorer prog CLL
8
NIGHT SWEATS
CLL
9
CTLA-4
binds B7
prevents runaway T-cell activity
10
Location of MHC I synthesis
RER
11
TAP 1 and 2
gets antigen into RER for upload on MHC I
12
ERAAP
inside RER
helps load antigen onto MHC I
13
Location of antigen loading onto MHC II
late endosome
14
"place holder" on MHC II
invariant chain
15
part of digested invariant chain left in MHC II
CLIP
16
replaces CLIP with antigen on MHC II
HLA-DM
17
inhibits HLA-DM
HLA-DO
18
location of invariant chain loading onto MHC II
RER
19
licenses DCs to cross present
CD40--CD40L
20
CD40 on what cell
DC
21
CD40L on what cells
Th's
22
MHC II expression stimulated by
INF-y
23
TdT alone
early pro-B cell
24
TdT and CD45R
intermediate pro-B-cell
25
CD45R
downregulated TdT
Late pro-B cell
26
receptor for B cell growth and differentiation
CD45R
27
pro-B cell, chain recombination?
H-chain
DJ--VDJ
28
pre-B cell, chain recombination?
L-chain
V-J
**small pre-B cell
29
cytokine for B cell division and differentiation
IL-7
30
Btk
Bruton's tyrosine kinase
XLA
no/few B-cells
31
reduced serum IgG, memory B cells
CVID
32
Prototypical TI-1 antigen
(T cell independent)
LPS
33
TI-2 antigen
large polysaccharides
34
TLR4 TI 1 B cell activation
polyclonal
35
BCR TI 1 B cell activation
clonal
36
B1 B cells bind type 2 TI antigens via...
cross-linking of BCR
clonal
37
"handcuffs" T-cell to APC ---> too many Th1's!
superantigen
38
CTL-Ps activated by..
licensed APCs
39
APCs licensed by...
Th1
Th17
PAMP+TLR
40
CTL-P activation molecules (4)
TCR--MHC I
CD28--CD80/86
41
no IL-2 or CD25(IL-2R)
high L-selectin and CCR7
low CD44 and LFA-1
naive CTL-P
42
CTL-P homing and retention in the lymph node
CCR7
43
CTL Effector homing and retention at sites of inflammation
CD44 and LFA-1
44
LFA-1
on CTL
binds ICAMs on target cell
45
most effective NKs at killing target cells
CD56 low
46
NK activity stimulated by:
INF-a
INF-B
INF-y
TNF-a
IL-15
47
CD16
NKs
recognizes IgG
48
only inhibitory NK lectin-like receptor
CD94 aka NKG2A
**trumps everything
49
only activating NK immunoglobulin-like receptor
KIR2DS1
50
activation of NK cell
must bump into inhibitory signal at least once
51
CMD
neutrophils
CML
52
CMD
RBCs
Polycythemia vera
53
CMD
platelets
Essential thrombocythemia
54
CMD
everything
Myelofibrosis
55
Basophilia
CML
56
Philadelphia
CML
57
Jak-2 mutation
Polycythemia vera
58
Plethora (flushing)
Polycythemia vera
59
high platelet count in YOUNG WOMEN
Essential thrombocythemia
60
Massive extramedullary hematopoiesis
Teardrop red cells
Chronic myelofibrosis
61
t(9;22)
CML
62
BCR-ABL
CML
63
auto inhibitor of ABL1
Myristate
64
added from BCR
creates new binding site for intracellular signalling
Tyrosine-177
65
specific ABL kinase inhibitor
Imantinib
66
monoclonal plasma cell proliferation
osteolytic lesions
Multiple myeloma
67
Bence-Jones proteins
Multiple myeloma
68
stacking of RBCs like coins
rouleaux
multiple myeloma
69
amyloid in marrow from light chain aggregates
multiple myeloma
70
Plasma cell tumor
IgM
Waldenstrom macroglobulinemia
71
classic triad for MM:
anemia
bone pain
renal failure
72
CD5+ B cells
CLL
73
bcl-2 rearrangment
CLL
74
Splenomegaly without lymphadenopathy
TRAP+
Hairy Cell Leukemia
75
CD25+
CD11c+
CD5-
Hairy Cell Leukemia
76
T-cell CLL
neutropenia
Large Granulated Lymphocytic Leukemia
77
Tingible body macrophages
Follicular hyperplasia
78
Partial effacement
T-cell response to immune stimulus
Interfollicular hyperplasia
79
Lymphoma
same as CLL
Small Lymphocytic Lymphoma
80
t(11;14)
Mantle Cell Lymphoma
81
t(14;18)
Follicular Lymphoma
82
"butt cells"
Follicular Lymphoma
83
Cerebriform lymphocytes
Skin lesions
T-cell
Mycosis Fungoides
84
Large mitotically active B cells
Diffuse Large Cell Lymphoma
85
Lymphoma same as ALL
Lymphoblastic
86
Teenage male with mediastinal mass
Lymphoblastic lymphoma
87
Starry-sky
Burkitt Lymphoma
88
t(8;14)
Burkitt Lymphoma
89
Reed-Sternberg cells
Hodgkin Lymphoma
90
Popcorn cells
Nodular L-P Hodgkin Lymphoma
91
Lacunar cells
Nodular Sclerosis Hodgkin Lymphoma
92
Collagen or reticulin background
Lymphocyte depletion Hodgkin Lymphoma
93
therapy induced lung disease
bleomycin
94
anti-CD20 "difference maker" tx
rituximab
95
prototypical agressive NHL
Diffuse Large B Cell
96
cyclin D+
Mantle Cell Lymphoma
97
H. pylori
MALT Lymphoma
98