Thrombotic Disorders Flashcards Preview

IHO week 6 and Final > Thrombotic Disorders > Flashcards

Flashcards in Thrombotic Disorders Deck (16):
1

Most common hereditary thrombotic disorder:

Factor V Leiden

VERY rare in non-caucasians

2

Dx fro factor V Leiden?

genetic testing

**point mutation in factor V gene

3

What's the problem with defective factor V?

Can't be cleaved by protein C

4

Natural anticoagulant

inhibits IIa, VIIa, IXa, Xa, XIa

potentiated by heparin

antithrombin III

5

Warfarin induced skin necrosis; think....

Protein C or S deficiency

**gets knocked out before clotting factors

6

inactivates Va and VIIIa

promotes t-PA action

keeps cytokines low

protein C

7

thrombotic state + vascular injury = ?

Purpura fulminans

8

Super rare, same as protein C def?

protein S def

9

Mutated gene makes too much thrombin:

Factor II mutation

rare in non-caucasians

10

What is factor II?

prothrombin

11

MTHFR gene mutation?

Homocysteinemia

12

To bad things about homocyteine with regardds to thrombosis:

forms ROS --> endothelial damage

interferes with NO (vasodilator and antithrombotic)

13

Other way to get homocysteinemia besides MTHFR?

B12/folate deficiency

**less worrisome

14

Falsely prolonged INR

autoantibody involvement

Antiphospholipid Antibodies

15

Inhibitors (antiphospholipid antibodies) in vivo _________ coagulation.

Promote

16

Inhibitors (antiphopholipid antibodies) in vitro ________ coagulation.

Inhibit