HIV Flashcards Preview

IHO week 6 and Final > HIV > Flashcards

Flashcards in HIV Deck (16)
Loading flashcards...
1
Q

HIV classification and characteristics:

A

o Genome: 2 copies of positive polarity RNA

o Capsid symmetry: Icosahedral

o Envelope: Yes; includes gp120 and gp41 (mediate interaction between viral partical and host cell)

o Tropism: CD4+ T cells (also CD4+ monocytes, macrophages)

o Reverse transcriptase + integrase + protease = 3 E that come with the virus

2
Q

capsid protein detectable by ELISA for dx:

A

p24

3
Q

3 viral enzymes:

A

Reverse transcriptase

integrase

protease

4
Q

2 envelope glycoproteins:

A

gp 120

gp 41

5
Q

viral protein that binds CD4:

A

gp 120

6
Q

viral protein binds chemokine R, initiates fusion with host plasma membrane

A

gp 41

7
Q

What does reverse transcriptase do?

Where does it do it?

A

ssRNA –> ssDNA –> dsDNA

cytoplasm

8
Q

Enzyme that gets viral dsDNA into host DNA?

A

integrase

9
Q

last viral enzyme used to package new viruses?

A

protease

10
Q

what makes the new viral RNA and mRNA?

A

host RNA pol 2

11
Q

How is HIV tested for?

A

ELISA for anti-p24 antibodies

then

confirm with Western Blot

12
Q

which two enzymes are required for formation of the provirus?

A

reverse transcriptase

integrase

13
Q

major cause of CD4 cell loss in HIV?

A

binding of viral envelope proteins expressed on infected cell surface binds to CXCR4 –> autophagy

14
Q

co-receptors for viral binding to host cell:

A

CXCR4

CCR5

15
Q

gag?

A

capsid proteins

ie. p24

16
Q

Mutation leading to resistance to HIV infection?

A

CCR5