Drugs for final buzzwords Flashcards Preview

IHO week 6 and Final > Drugs for final buzzwords > Flashcards

Flashcards in Drugs for final buzzwords Deck (45):
1

FGF inhibitors

TERATOGENIC (phocomelia)

Thalidomide


also: lenalidomide, Pomalidomide

2

STI of VEGF

Raf

CHF/MI, teratogenic

HTN, hemorrhage

SoRAFinib

3

STI of VEGF

cKIT

skin discoloration

Sunitinib

4

STI of VEGF

cKIT

Fatal Hepatotoxicity

Torsuad's, prolonged QT

Pazopanib

5

Methotrexate overdose rescue

Glucarpidase

6

t(15;17) AML M3

induces differentiation

trentinoin, arsenic trioxide

ATRA

7

retinoid receptor agonist

increased cell differentiation--> death

bexarotene

8

Protects bladder from Cyclophosphamide

MESNA

9

fusion protein analog of thrombopoietin

Romiplostim

10

26s proteosome

Bortezomib (reversible)

Carfilzomib (irreversible)

11

HDAC

cutaneous t cell lymphoma

Vorinostat

Romidepsin

12

HER2 STIs

Trastuzamab

Pertuzumab

13

EGFR STIs

ATP binding site competitors and MABs

CETUXIMAB

ERLOTINIB

GEFITINIB

PANITUMUMAB

14

BCR-ABL STI

imatinib

15

FK-binding protein

immunosupressor

Antibiotic

Tacrolimus

16

CD20

rituximab

17

CD52

alemtuzumab

18

VEGF MAB

used with 5-FU

Bevacizimab

19

ribonucleotide reductase

syncronizes cell in radiation sensitive G1 phase

Hydroxyurea

20

treats Tumor Lysis Syndrome from 6-MP

allopurinol


**decrease 6-MP

21

Allows higher dose of MTX

Reduced folate carrier uptake

Leukovorin

22

DNA pol inh.

--abines

**except fludarabine

23

ribonucleotide reductase

purine analog

fludarabine

24

Purine analogs

PNP

HGPRT

6-MP

6-TG

25

most toxic nitrogen mustard

alkylating agent

mechlorethamine

26

nitrogen mustard

alkylating agent

Hemorrhagic cystitis

cyclophosphamide

27

nitrosoureas

crosslink DNA

lipid soluble

Carmustine

Lomustine

28

HIV drugs

4 nucleoSide RTIs

Zidovudine (Azidothymidine or AZT)

Lamivudine

Emtricitabine

Abacavir

29

HIV drugs

1 nucleoTide RTI

Tenofivir

30

2 NNRTIs

Efavirenz

Etravirine

31

HIV drugs

3 protease inhibitors

Ritanovir

Atazanavir

Darunavir

32

HIV drug

fusion inhibitor

binds gp 41

Enfuvirtide

33

HIV drug

integrase inhibitor

Raltegrovir

34

HIV drug

binds HOST CCR5

Maraviroc

35

Antiplatelet drugs

ADP analogs

** CLOP CLOP PRA

Clopidogrel

Ticlopidine

Prasugrel

36

Antiplatelet drugs

GP IIb/IIIa inhibitors

**EAT

Eptifibatide

Abciximab

Tirofiban

37

Antiplatelet drug

Increases cAMP

Phosphodiesterase 3 inhibitor

vasodilator

use in combo w/ASA or Warfarin

Dipyridamole

38

Indirect thrombin inhibitors

bind AT III

inhibit thrombin and Xa

heparins

Fondaparinux

39

Antidote for heparin OD

Protamine

40

Bind directly to thrombin

**BAD

Bivalirudin

Argatroban

Dabigatran

41

Direct Xa inhibitors

**RAE bans

Rivoroxaban

Apixaban

Edoxaban

42

vit K dependent clotting factors

II

VII

IX

X

Protein C

43

More active enantiomer of Warfarin

S

44

Two older fibrinolytics

Streptokinase

Urokinase

45

tPA fibrinolytics

**ART--teplases

Alteplase

Reteplase

Tenecteplase