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IHO week 6 and Final > Drugs for final buzzwords > Flashcards

Flashcards in Drugs for final buzzwords Deck (45)
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1

FGF inhibitors

TERATOGENIC (phocomelia)

Thalidomide


also: lenalidomide, Pomalidomide

2

STI of VEGF

Raf

CHF/MI, teratogenic

HTN, hemorrhage

SoRAFinib

3

STI of VEGF

cKIT

skin discoloration

Sunitinib

4

STI of VEGF

cKIT

Fatal Hepatotoxicity

Torsuad's, prolonged QT

Pazopanib

5

Methotrexate overdose rescue

Glucarpidase

6

t(15;17) AML M3

induces differentiation

trentinoin, arsenic trioxide

ATRA

7

retinoid receptor agonist

increased cell differentiation--> death

bexarotene

8

Protects bladder from Cyclophosphamide

MESNA

9

fusion protein analog of thrombopoietin

Romiplostim

10

26s proteosome

Bortezomib (reversible)

Carfilzomib (irreversible)

11

HDAC

cutaneous t cell lymphoma

Vorinostat

Romidepsin

12

HER2 STIs

Trastuzamab

Pertuzumab

13

EGFR STIs

ATP binding site competitors and MABs

CETUXIMAB

ERLOTINIB

GEFITINIB

PANITUMUMAB

14

BCR-ABL STI

imatinib

15

FK-binding protein

immunosupressor

Antibiotic

Tacrolimus

16

CD20

rituximab

17

CD52

alemtuzumab

18

VEGF MAB

used with 5-FU

Bevacizimab

19

ribonucleotide reductase

syncronizes cell in radiation sensitive G1 phase

Hydroxyurea

20

treats Tumor Lysis Syndrome from 6-MP

allopurinol


**decrease 6-MP

21

Allows higher dose of MTX

Reduced folate carrier uptake

Leukovorin

22

DNA pol inh.

--abines

**except fludarabine

23

ribonucleotide reductase

purine analog

fludarabine

24

Purine analogs

PNP

HGPRT

6-MP

6-TG

25

most toxic nitrogen mustard

alkylating agent

mechlorethamine

26

nitrogen mustard

alkylating agent

Hemorrhagic cystitis

cyclophosphamide

27

nitrosoureas

crosslink DNA

lipid soluble

Carmustine

Lomustine

28

HIV drugs

4 nucleoSide RTIs

Zidovudine (Azidothymidine or AZT)

Lamivudine

Emtricitabine

Abacavir

29

HIV drugs

1 nucleoTide RTI

Tenofivir

30

2 NNRTIs

Efavirenz

Etravirine