Flashcards in Degenerative Disease Deck (28)
What are common features of Neurodegenerative diseases?
Loss of neurons
What is the definition of dementia?
A syndrome consisting of progressive impairment of multiple domains of cognitive function in alert patients leading to loss of acquired skills & interference in social & occupational role
What are the main risk factors for dementia?
What are some of the causes of late onset dementia?
What are some of the causes of ealry onset dementia?
What are some of the OTHER causes of early onset dementia?
Infection (HIV, CJD)
What are some of the treatable causes of dementia?
Vit B12 deficiency
Endocrine - thyroid disease
Infective - HIV
What are some differentials associated with dementia?
What investigations may be done in dementia?
LP - CSF for inflammatory markers
What tests may you carry out on examination?
What domains of cognitive function does the MOCA test?
What are some clues to diagnosing dementia?
In which type of dementia would a stepwise progression be observed?
Which type of dementia is associated with Parkinsons?
What is the commonest neurodegenerative condition?
What symptoms will temporo-parietal dementia present with?
Early memory disturbance
Language & visuospatial problems
What symptoms will be observed in fronts-temporal dementia?
Early change in personality & behaviour
Memory relatively preserved
What non-pharmacological treatments can be supplied for dementia patient?
Information & support
What specific pharmacological treatments can be given for Alzheimers disease?
Anticholinsterases (Donepezil, rivastigmine)
NMDA antagonist (mematine)
What treatment can be given in FT dementia?
What is Parkinsons disease?
A clinical syndrome with >2 of:
Where is pathology observed in the brain of Parksinsons?
Loss of dominergic neurons in Basal ganglia
What are some of the causes of Parkinsons?
Idiopathic Parkinsons disease
What age does Parkinsons usually present?
What helps to confirm diagnosis of parkinson's?
Symptoms (bradykinesia & other symptom)
Response to dopamine replacement therapy
What type of medication can be given to parkinson's patient?
When can motor fluctuations be observed in parkinson's patient?
When Levodopa wears off