Flashcards in Muscle & Nerve Disease Deck (26)
What are the symptoms associated with muscle disease?
Weakness of muscle
What are the signs of muscle disease?
Reduced reflexes and tone
Motor weakness NOT sensory
What investigations associated with muscle disease would you carry out?
What are some of the congenital/ genetic classes of muscle disease?
What are some of the acquired causes of muscle disease?
Metabolic (low Ca, K)
Inflammatory muscle disease
What is the mutation observed in Duchennes muscular dystrophy?
What are the different types of dystrophies?
What channels do channel-patties affect
Ca, K, Na, Cl
In metabolic muscle disease, what are the different types?
What are the causes of metabolic muscle disease?
Disorders of CHO/ FA metabolism
What is inflammation of the muscle called?
What signalling molecule observed at the NMJ?
What is the clinical presentation of myasthenia gravis?
Muscles of mastication
What investigations are useful in MG?
Anti MuSK ab
What is the management for MG?
What fibres are present in a peripheral nerve?
Sensory afferent (small fibres - pain & temp, large fibres - touch, pressure, vib)
What general symptoms are observed in peripheral neuropathy?
(Moves from distal to proximal)
What are some of the causes of generalised peripheral neuropathy?
Guillain Barre syndrome
What symptoms will be observed in nerve rot disease?
Myotomal wasting & weakness
Dermatomal sensory change
What symptoms are observed in disease of individual nerve?
Wasting & weakness of innervated muscle
What are some of the investigations used for nerve disease?
Nerve conduction studies
What is another name for Motor Neuron disease?
Amyotrophic Lateral Sclerosis
What are some characteristic of the symptoms of MND?
Combination of UMN & LMN signs
No sphincter involvement
What UMN lesions are observed in MND?
What LMN lesions are observed in MND?