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Flashcards in Heart Development - WTF Deck (67)
1

Before birth, how is blood shunted?

From right to left atrium

2

When does heart formation begin and when does heart start beating?

3 weeks
4 weeks

3

Initial function of heart

One way pump to transport O2 blood from placenta to the embryo

4

Umbilical vein function

Carries blood from placenta to embryo

5

Umbilical arteries functionm

Carry blood from embryo to placenta

6

Cardiogenic region...where is it and what happens?

At the rostral end...mesodermal cells aggregate to form longitudinal cellular strands (angioblastic cords)

7

What germ layer is the majority of the heart composed from?

Splanchnic mesoderm

8

How is primitive heart tube formed?

Angioblastic cords hollow out to form endocardial heart tubes

9

What does longitudinal folding accomplish for the heart?

Positions it in the thorax

10

Embryonic folding brings

Two endocardial tubes into the thorax where they meet along midline and fuse to form a single tube

11

Fused endocardial tubes form the ______

Inner lining of the heart
Endocardium

12

What happens to mesoderm below pericardial coelom as heart tube fuses?

Forms cardiac jelly and myocardium

13

Pericardial coelom is the future _______

pericardial cavity

14

Cardiac jelly

Thick, inner gelatinous mix

15

Myocardium

Muscular layer

16

Parietal pericardium is from ______ mesoderm

Somatic

17

Visceral pericardium from ______ mesoderm

Somatic

18

Dorsal mesocardium does what and then leaves what remnant?

Anchors heart at the beginning and goes away to form transverse pericardial sinus

19

Flow through the parts of pirmitive heart tube

Sinus venosus------atrium-----ventricle------bulbis cordis--------truncus arteriosis---------aortic arch vessels

These are caudal to rostral

20

Pericardial sac from what parts of the primitive heart tube?

Ventricle
Bulbis cordis
Truncus arteriosis

21

Truncus arteriosis becomes

Pulmonary trunk

22

How does sinus venosus receive blood

Common cardinal veins (body)
Umbilical veins (placenta)
Vitelline veins (yolk sac)

23

Blood flows from the aortic arches into the _________ to reach the body, placenta, and yolk sac

DOrsal aortae

24

Dextrocardia`

Heart abnormally positioned on the right side of the thorax

25

Dextrocardia with situs inversus

No cardiac abnormality because inversion of all organs

26

Four sets of partitions of primitive heart

Atria and ventricles
R and L atria
R and L ventricle
Pulmonary trunk and ascending aorta

27

Atrioventricular canal and what develops there during week 4

Between pirmitive atrium and ventricle
Endocardial cushions

28

Endocardial cushions grow together to create

Atrioventricular septum

29

Septum primum grows how?

From roof of atrium and extends toward endocardial cushions

30

Ostium primum

Opening between sptum primum and the endocardial cushions

31

How does septum secundum grow?

From roof immediately to the right of the septum primum

32

Part septum secundum and the septum primum grows to touch the

Endocardial cushions that formed the membranous portion of IV septum

33

Blood circulation before birth

Foramen ovale shunts blood entering the right atriumn into the left atrium and prevents passage moving oppostie way

34

After birth, what happens to foramen ovale?

Septum primum and secundum pressed together to form fossa ovalis

35

What causes foramen ovale closure?

Decreased RA pressure and increased LA pressure

36

Atrial septal defects

INcomplete anatomical fusion of septum primum and secundum

37

How does right atrium remodel its wall?

Right side of sinus venosus incorporated into the side of the atrium

38

Sinus venarum

Part of atrium that contains incorporated sinus venosus

39

Original right side of primitive atrium becomes

Right auricle

40

Left atrium wall remodeling

Incorporation of pulmonary vein

41

Pulmonary vein divids to produce ____

4 pulmonary veins

42

4 pulmonary veins anastomose with

Veins developing in mesoderm around bronchial buds

43

Left side of primitive atrium becomes the

Left auricle

44

What must be partitioned to create pulmonary trunk and ascending aorta and what are their parts called

Bulbis cordis and truncus arteriosis
Truncal and bulbar ridges

45

Formation of aorticopulmonary trunk creates

two outflow paths

46

Truncal and bulbar ridges made from

neural crest cells

47

Shape of wall of aorticopulmonary segment

Spiraling

48

Two sections of IV septum

Membranous - from endocardial cushions
Muscular -

49

Persistant truncus arteriosis

Abnormal neural crest cell migration so only partial AP septum
ONly a large vessel leaves the heart and receives blood from both
Cyanosis

50

Transpotion of great arteries

Aorticopulmonary septum is straight line rather than spiral
Aorta is from RV and pulmonary trunk from LV
Fatal unless patent ductus arteriosis
Most common cause

51

Tetraology of Fallot

Abnormla neural crest cell migration
Truncus arteriosis not divided equally
Pulmonary stenosis and overriding aorta
Results in VSD

52

Pulmonary stenosis and overriding aorta

Small pulmonary trunk diameter
Aorta large diameter

53

4 signs of tetraology of fallot (actually 5)

Pulmonary stenosis
Right ventricle hypertrophy
Overriding aorta
VSD
Cyanosis

54

Most VSDs shunt blood from

Left to right

55

Result of VSD

pulmonary hypertension

56

types of VSD

Membranous (most common)
Muscular
Common ventricle

57

Persistent atrioventricular canal is a result of

Endocardial cushions failing to fuse to atrial and ventricular septa

58

Primitive atria becomces

Auricles of right and left atria

59

Right horn of sinus venosus becomes

Smooth part of right atrium (sinus venarum)

60

Left horn of sinus venosus becomes

Coronary sinus

61

Primitive pulmonary veins becomes

Smooth part of left atrium

62

Conus cordis becomes

Outflow for both ventricles
Conus arteriosis (RV)
Aortic vestibule (LV)

63

Bulbis cordis becomes

Trabeculated RV

64

Primitive ventricle becomes

Trabeluated LV

65

Truncus arteriosis becomes

Ascending aorta and pulmonary track

66

Ductus arteriosis shunts blood from

Pulmonary artery to the aorta

67

Foramen ovale shunts blood from the

Right atrium to the left atrium