Flashcards in Introduction to neurones, nerve conduction and synaptic transmission Deck (48)
What are the major amine neurotransmitters?
What are the major peptic neurotransmitters?
Thyrotropin releasing hormone
Vasoactive intestinal polypeptide
Which neurotransmitters are released from synaptic vesicles?
Which neurotransmitters are released from secretory vesicles?
Which neurotransmitters mediate fast neurotransmission via inotropic ligand gated ion channels?
Which neurotransmitters mediate slow neurotransmission via metabotropic G-protein coupled receptors?
All except glycine
What are the modes of neurotransmission?
How does direct neurotransmission work?
The receptor is an integral component of the molecule that forms the channel is controls
Gating of channel is rapid
How does indirect neurotransmission work?
Mediated by activation of metabotropic receptors
Receptor and the channel it controls are distinct
Gating of channel is slower
Which channels does fast EPSP utilise?
Activation of nicotinic ACh receptors
Conduction of Na+ and K+
Which channels does slow EPSP utilise?
Activation of muscarinic G coupled ACh receptors
Close of M-type K+ channels
Which is the major excitatory neurotransmitter?
What channels will glutamate bind to?
Non-NMDA receptors to bind the agonist kainate or AMPA controlling Na+ and K+
NMDA receptors controlling channels permeable to Na+ , Ca 2+, K+
Which mode of transmission will non-NMDA ionotropic receptors (AMPA and kainate) mediate?
Fast excitatory synaptic transmission in the CNS
Which mode of transmission will NMDA mediate?
Slow component to excitatory synaptic potential
Which ion will NMDA receptors have a high permeability to?
Which drugs act on NMDA receptors?
Psychotomimetic agents such as phencyclidine