Introduction to neurones, nerve conduction and synaptic transmission Flashcards Preview

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Flashcards in Introduction to neurones, nerve conduction and synaptic transmission Deck (48)
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31

What are the major amine neurotransmitters?

Dopamine
Histamine
Noradrenaline
Serotonin

32

What are the major peptic neurotransmitters?

Cholecystokinin
Dynorphin
Enkephalins
Neuropeptide Y
Somatostatin
Substance P
Thyrotropin releasing hormone
Vasoactive intestinal polypeptide

33

Which neurotransmitters are released from synaptic vesicles?

Acetylcholine
Amino acids
Amines

34

Which neurotransmitters are released from secretory vesicles?

Peptides

35

Which neurotransmitters mediate fast neurotransmission via inotropic ligand gated ion channels?

Glutamate
GABA
Glycine
Acetylcholine
Serotonin

36

Which neurotransmitters mediate slow neurotransmission via metabotropic G-protein coupled receptors?

All except glycine

37

What are the modes of neurotransmission?

Direct
Indirect

38

How does direct neurotransmission work?

Ionotropic receptors
The receptor is an integral component of the molecule that forms the channel is controls
Gating of channel is rapid

39

How does indirect neurotransmission work?

Mediated by activation of metabotropic receptors
Receptor and the channel it controls are distinct
Gating of channel is slower

40

Which channels does fast EPSP utilise?

Activation of nicotinic ACh receptors
Conduction of Na+ and K+

41

Which channels does slow EPSP utilise?

Activation of muscarinic G coupled ACh receptors
Close of M-type K+ channels

42

Which is the major excitatory neurotransmitter?

Glutamate

43

What channels will glutamate bind to?

Non-NMDA receptors to bind the agonist kainate or AMPA controlling Na+ and K+
NMDA receptors controlling channels permeable to Na+ , Ca 2+, K+

44

Which mode of transmission will non-NMDA ionotropic receptors (AMPA and kainate) mediate?

Fast excitatory synaptic transmission in the CNS

45

Which mode of transmission will NMDA mediate?

Slow component to excitatory synaptic potential

46

Which ion will NMDA receptors have a high permeability to?

Ca 2+

47

Which drugs act on NMDA receptors?

Ketamine
Psychotomimetic agents such as phencyclidine

48

Which pathway relies on ionotropic and metabotropic glutamate receptors?

Retinal