Muscle & Nerve Disease Flashcards Preview

Neurology > Muscle & Nerve Disease > Flashcards

Flashcards in Muscle & Nerve Disease Deck (26)
1

What are the symptoms associated with muscle disease?

Weakness of muscle
Breathing problems
Poor swallowing
Cardiomyopathy
Cramp
Pain, stiffness

2

What are the signs of muscle disease?

Wasting/ weakness
Reduced reflexes and tone
Motor weakness NOT sensory

3

What investigations associated with muscle disease would you carry out?

CK
EMG
Muscle Biopsy

4

What are some of the congenital/ genetic classes of muscle disease?

Muscular dystrophies
Congenital myopathies
Channelopathies
Enzyme

5

What are some of the acquired causes of muscle disease?

Metabolic (low Ca, K)
Endocrine
Inflammatory muscle disease
Iatrogenic

6

What is the mutation observed in Duchennes muscular dystrophy?

Dystrophin protein

7

What are the different types of dystrophies?

Duchennes
Beckers
Myotonic dystrophy
Limb-Girdle

8

What channels do channel-patties affect

Ca, K, Na, Cl

9

In metabolic muscle disease, what are the different types?

Exercise induced
Fixed weakness

10

What are the causes of metabolic muscle disease?

Disorders of CHO/ FA metabolism
Mitochondrial myopathies

11

What is inflammation of the muscle called?

Polymyositis

12

What signalling molecule observed at the NMJ?

Ach

13

What is the clinical presentation of myasthenia gravis?

Fatiguable weakness
Limbs
Eyelids
Muscles of mastication
Swallow
Talking
SOB
diplopia

14

What investigations are useful in MG?

AChR ab
Anti MuSK ab
Neurophysiology

15

What is the management for MG?

Anticholinesterase
Immunosuppression
Prednisolone

16

What fibres are present in a peripheral nerve?

Sensory afferent (small fibres - pain & temp, large fibres - touch, pressure, vib)
Motor efferent
Autonomic axons

17

What general symptoms are observed in peripheral neuropathy?

Motor
Sensory
(Moves from distal to proximal)

18

What are some of the causes of generalised peripheral neuropathy?

Diabetes
Alcohol
VitB12 déficiency
Drugs
Lyme disease
HIV
Guillain Barre syndrome

19

What symptoms will be observed in nerve rot disease?

Myotomal wasting & weakness
Reflex change
Dermatomal sensory change

20

What symptoms are observed in disease of individual nerve?

Wasting & weakness of innervated muscle

21

What are some of the investigations used for nerve disease?

Blood tests
Nerve conduction studies
Lumbar puncture
Nerve biopsy

22

What is another name for Motor Neuron disease?

Amyotrophic Lateral Sclerosis

23

What are some characteristic of the symptoms of MND?

Combination of UMN & LMN signs
Sensation spared
No sphincter involvement

24

What UMN lesions are observed in MND?

Increased tone
Brisk reflexes

25

What LMN lesions are observed in MND?

Wasting
Fasciculations
Weakness

26

What supportive treatment can be given in MND?

SALT
Physio
OT
PED feed
Non-invasive ventilation