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Flashcards in Neoplasia Deck (46)
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1

slow growing, encapsulated mass of orderly cells, no invasion

benign tumor

2

fast growing, invasive mass of disorderly cells, not encapsulated

malignant tumor

3

tumor is large and localized

primary malignancy

4

tumor is small and multifocal

metastatic malignancy

5

genetic mutation linked with some cancers

oncogene

6

gene which governs the growth of normal tissue

proto-oncogene

7

chemicals, radiation, or germs that may cause cancer

carcinogens

8

agents capable of causing genetic material; may cause cancer

mutagens

9

change in one base; neurofibromatosis, adenomatous polyposis coli

DNA point mutation

10

gene segments are exchanged; Burkitt's lymphoma, leukemia

translocation

11

gene segment is duplicated; N-myc is neuroblastoma

amplification

12

gene which prevents normal cells from becoming malignant

cancer suppressor gene

13

inactivation of cancer suppressor genes; BRCA in breast cancer

anti-oncogenes

14

Starry-sky appearance on histo; HHV type 4 ARBO virus

Burkitt's lymphoma

15

Binucleated cells; associated with Hodgkin's lymphoma

Reed Sternberg cells

16

ARBO virus linked with Burkitt's lymphoma

Epstein-Barr virus

17

Linked with hepatocellular carcinoma

Hepatitis C

18

Malignant plasma cells, Bence Jones protein, recurrent infections

multiple myeloma

19

benign smooth muscle tumor in the uterus

uterine leiomyoma

20

Blood malignancy with numerous immature WBC's

leukemia

21

leukemia m/c in young children

acute lymphocytic leukemia

22

leukemia associated with Auer rods in adults

acute myelogenous leukemia

23

leukemia associated with the Philadelphia chromosome

chronic myelogenous leukemia

24

translocation involving chromosome 9 and 22

Philadelphia chromosome

25

leukemia m/c in 60+ patients; asymptomatic

chronic lymphocytic leukemia

26

linked with nitrosamine and alcohol use; squamous cell type

esophageal cancer

27

linked with exposure to asbestos; malignancy of the pleura

mesothelioma

28

linked with exposure to benzene

Leukemia

29

linked with exposure to aflatoxin for moldy groundnuts or corn

hepatocellular carcinoma

30

linked with exposure to uranium and smoking

lung cancer