Flashcards in NMJ and muscle pathologies Deck (51)
What is the pattern of muscle disease in polymyositis?
Progressive proximal weakness developing over weeks to months
What test will help in the diagnosis of polymyositis?
Difference between polymyositis and dermatomyositis?
Dermatomyositis will show cutaneous features such as heliotrope rash and shawl sign
Also has a 50% recurrence with an underlying malignancy
What is the presentation of inclusion body myositis?
Slowly progressive weakness in the 6th decade with characteristic thumb sparing
What is the inheritance of myotonic dystrophy?
AD of trinucleotide repeat disorder with anticipation
What is the presentation of myotonic dystrophy?
What are the inherited muscular dystrophies?
Duchenne and Becker
What infective causes can result in muscle disease?
What are some common drugs that cause myopathy?
Necrotising myopathies; stating, fibrates
Lysosomal storage myopathy; hydroxychloroquine, amiodarone
Hypokalemic myopathy; diuretics, OCP
What is rhabdomyolysis?
Damage to skeletal muscle causes leakage of large quantities of toxic intracellular contents into the plasma such as myoglobin
What can cause rhabdomyolysis?
What is the triad of rhabdo?
What are common complications of rhabdo?
What should be tested in examination of muscles?
Inspection; thin, wasted, fasciculations
What does 0 on the MRC muscle power grading mean?
No movement at all
What does 1 on the MRC muscle power grading mean?
Flicker of movement when attempting to contract the muscle
What does 2 on the MRC muscle power grading mean?
Some muscle movement if gravity removed but none against gravity
What does 3 on the MRC muscle power grading mean?
Movement against gravity but not against resistance
What does 4 on the MRC muscle power grading mean?
Movement against resistance but not full strength
What does 5on the MRC muscle power grading mean?