NMJ and muscle pathologies Flashcards Preview

Neurology > NMJ and muscle pathologies > Flashcards

Flashcards in NMJ and muscle pathologies Deck (51)
Loading flashcards...
31

What is the pattern of muscle disease in polymyositis?

Symmetrical
Progressive proximal weakness developing over weeks to months

32

What test will help in the diagnosis of polymyositis?

Raised CK
Muscle biopsy
EMG

33

Difference between polymyositis and dermatomyositis?

Dermatomyositis will show cutaneous features such as heliotrope rash and shawl sign
Also has a 50% recurrence with an underlying malignancy

34

What is the presentation of inclusion body myositis?

Slowly progressive weakness in the 6th decade with characteristic thumb sparing

35

What is the inheritance of myotonic dystrophy?

AD of trinucleotide repeat disorder with anticipation

36

What is the presentation of myotonic dystrophy?

Myotonic
Weakness
Cataracts
Ptosis
Frontal balding
Cardiac defects

37

What are the inherited muscular dystrophies?

Duchenne and Becker

38

What infective causes can result in muscle disease?

Viral; coxsackie
Trypanosomiasis
Cisticercosis
Borrelia

39

What are some common drugs that cause myopathy?

Necrotising myopathies; stating, fibrates
Corticosteroid myopathy
Lysosomal storage myopathy; hydroxychloroquine, amiodarone
Hypokalemic myopathy; diuretics, OCP

40

What is rhabdomyolysis?

Damage to skeletal muscle causes leakage of large quantities of toxic intracellular contents into the plasma such as myoglobin

41

What can cause rhabdomyolysis?

Crush injuries
Toxins
Post-convulsions
Extreme exercise

42

What is the triad of rhabdo?

Myalgia
Muscle weakness
Myoglobinuria

43

What are common complications of rhabdo?

AKI
DIC

44

What should be tested in examination of muscles?

Inspection; thin, wasted, fasciculations
Palpation
Strenth
Neck strength
Core strength
Fatiguability

45

What does 0 on the MRC muscle power grading mean?

No movement at all

46

What does 1 on the MRC muscle power grading mean?

Flicker of movement when attempting to contract the muscle

47

What does 2 on the MRC muscle power grading mean?

Some muscle movement if gravity removed but none against gravity

48

What does 3 on the MRC muscle power grading mean?

Movement against gravity but not against resistance

49

What does 4 on the MRC muscle power grading mean?

Movement against resistance but not full strength

50

What does 5on the MRC muscle power grading mean?

Normal strength

51

Is 4 on the MRC muscle power grading split up?

Yes; can be 4+ or 4-